Figure 9. SOD1 and iNOS expression in rat lung tissue. Immunocytochemical labeling for SOD1 (a-d) and iNOS (e-h), in lungs of control (a and e), CdCl₂- (b and f), SiNPs-Cd- (c and g), and SiNPs- treated rats (d and h). The SOD1 expression was evidenced after both CdCl₂ and Cd-SiNPs treatments, 7 days post-instillation (b and c, arrows). Primarily detected at alveolar level (i.e. macrophages). The iNOS labelling was mainly observed in clusters of the inflammatory cells (arrows), surrounding the alveolar capillary wall, after both CdCl₂ and Cd-SiNPs exposure (f and g, respectively). SiNP-treated rats showed immunostaining patterns of SOD1- and iNOS-expression comparable to those observed in controls (d and h, respectively). Scale bar: 200 microm (a-h)

From

An integrated in Vitro and in Vivo Testing Approach to Assess Pulmonary Toxicity of Engineered Cadmium-Doped Silica Nanoparticles

Uliana De Simone, Elisa Roda, Cinzia Signorini, Teresa Coccini

• Previous
• Figure 9 of 10  (Figures index)
• Next