Figure 8. Lung histology. Representative lung parenchyma specimens, investigated by both Light (H&E) and Electron microscopy (a-c and d-f, respectively), from control (a) and Cd-SiNPs-treated rats, 7 days after i.t. instillation (b-f). Selected structural alterations evidenced in pulmonary parenchyma of Cd-SiNPs treated rats are presented. (a) normal, physiological alveolar and bronchiolar morphology; (b) bronchus-associated lymphoid nodule adjacent to granulomatous formation (arrow and thin arrow, respectively) in both peribronchiolar and perivascular area; (c) collapsed alveoli characterized by wall thickening and micro hemorrhagic foci, along with bronchiolar distortion and epithelial cell desquamation (arrow); (d) edematous alveolar wall (arrow) and type II pneumocytes (PII) packed with vacuolized multi-vescicular bodies; (e) activated alveolar macrophage (AM), typically characterized by the presence of cytoplasmic phagosomes and residual bodies; (f) activated Club cells (Cc) detected in the apical region of bronchiolar epithelium. Light microscopy scale bar: 200 microm (a-c). (Electron Microscopy original magnification: (d-e) x 4400; (f) x 3000)

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An integrated in Vitro and in Vivo Testing Approach to Assess Pulmonary Toxicity of Engineered Cadmium-Doped Silica Nanoparticles

Uliana De Simone, Elisa Roda, Cinzia Signorini, Teresa Coccini

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