Figure 7. TUNEL Labelling Index modifications at two time points. Histograms showing changes in TUNEL Labelling Index percentage of lung cells, caused by i.t. instillation of Cd-SiNPs versus CdCl2 or SiNPs, investigated at 1 and 7 days-post-treatment. In all exposed groups, a significant increase of apoptotic cells was evidenced, more manifest 1 day post-exposure, displaying the tendency to lessening with time, showing the following trend: Cd-SiNPs > CdCl2 > SiNPs. Data are expressed as mean ± SD, (*) indicates statistically significant differences (P < 0.05) compared to the respective control. Diverse letters (a-c) denote mean values that are statistically different at P < 0.05: comparison is between one time point versus the one immediately before of the same group : An integrated in Vitro and in Vivo Testing Approach to Assess Pulmonary Toxicity of Engineered Cadmium-Doped Silica Nanoparticles : Science and Education Publishing

Figure 7. TUNEL Labelling Index modifications at two time points. Histograms showing changes in TUNEL Labelling Index percentage of lung cells, caused by i.t. instillation of Cd-SiNPs versus CdCl₂ or SiNPs, investigated at 1 and 7 days-post-treatment. In all exposed groups, a significant increase of apoptotic cells was evidenced, more manifest 1 day post-exposure, displaying the tendency to lessening with time, showing the following trend: Cd-SiNPs > CdCl₂ > SiNPs. Data are expressed as mean ± SD, (*) indicates statistically significant differences (P < 0.05) compared to the respective control. Diverse letters (a-c) denote mean values that are statistically different at P < 0.05: comparison is between one time point versus the one immediately before of the same group

American Journal of Nanomaterials. 2015, 3(2), 40-56 doi:10.12691/ajn-3-2-1