Figure 10. Total F2-IsoPs levels in lungs and free F2-IsoPs levels in plasma of treated animals. Both pulmonary and plasma F2-IsoPs levels have been evaluated at 1, 7 and 30 days after i.t. exposure to Cd-SiNPs, CdCl₂, SiNPs. Data are means ± SD. Differences between groups were evaluated using two-tailed t test and P value < 0.05 was considered statistically significant (*). (Modified from Coccini et al. [48])

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An integrated in Vitro and in Vivo Testing Approach to Assess Pulmonary Toxicity of Engineered Cadmium-Doped Silica Nanoparticles

Uliana De Simone, Elisa Roda, Cinzia Signorini, Teresa Coccini

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