Figure 5. The effects of SFN on p65 phosphorylation, histone acetylation and HDAC3 expression in LPS-stimulated BMDMs. (A) p65 and p-p65 protein expression. (B) Representative picture of HDAC3, acyl-H4 and acyl-H3. ^# P<0.05, ^## P<0.01, ^### P<0.001 as compared to control (unstimulated cells), ^* P<0.05, ^** P<0.01, ^*** P<0.001 as compared to only LPS-stimulated cell. ^Ψ P<0.05, ^ΨΨ P<0.01, ^ΨΨΨ P<0.001 as compared to SFN at 10 μM. n = 3, bars represent mean ± S.D

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Sulforaphane (SFN) Exerts Anti-inflammatory Effects on LPS-stimulated RAW 264.7 and Mouse Bone Marrow Driven Macrophages by Modulating p65 Phosphorylation and Histone Acetylation

Seok-Yeong Yu, Zhenhua Liu, Soonkyu Chung, Young-Cheul Kim

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