Figure 2. Structural representation and molecular interactions of Cobalt Amide ligand 1 with the Nav1.7 voltage-sensor domain IV (VSD4). (a) Three-dimensional structure of the Nav1.7 VSD4 region bound to Cobalt Amide ligand 1. (b) Detailed representation of the interactions between Cobalt Amide ligand 1 and the surrounding amino acid residues in the VSD4 binding pocket, showing the key hydrogen-bonding, electrostatic, and hydrophobic interactions

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Amide Derivatives and Their Metal Complexes as Potential Nav1.7-Targeting Anesthetic Candidates

Temitayo O. Aiyelabola, Sayantan Pradhan, Takashiro Akitsu

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