Figure 8. The effect of FJH-BS on H2O2-induced changes in the mRNA expression of aggrecan (A), collagen type I (B), collagen type II (C), TIMP-1 (D), TIMP-2 (E), TIMP-3 (F), MMP-3 (G), MMP-7 (H), and MMP-13 (I) in primary chondrocytes. Normal Control: no treatment; Control: H2O2 200 μM treatment; MSM 10: H2O2 200 μM and MSM 10 μg/mL treatment; MSM 20: H2O2 200 μM and MSM 200 μg/mL treatment; FJH-BS 1: H2O2 200 μM and FJH-BS 1 μg/mL treatment; FJH-BS 5: H2O2 200 μM and FJH-BS 5 μg/mL treatment; FJH-BS 10: H2O2 200 μM and FJH-BS 10 μg/mL treatment; and FJH-BS 20: H2O2 200 μM and FJH-BS 20 μg/mL treatment. Values are presented as mean + SD (n=4). Different letters (a > b > c > d > e) indicate a significant difference with p < 0.05, as determined using the Duncan’s multiple range test : Standardized Ethanolic Extracts of Boswellia serrata Ameliorate Symptoms of Osteoarthritis by Direct Effects on Chondrocytes : Science and Education Publishing

Figure 8. The effect of FJH-BS on H₂O₂-induced changes in the mRNA expression of aggrecan (A), collagen type I (B), collagen type II (C), TIMP-1 (D), TIMP-2 (E), TIMP-3 (F), MMP-3 (G), MMP-7 (H), and MMP-13 (I) in primary chondrocytes. Normal Control: no treatment; Control: H₂O₂ 200 μM treatment; MSM 10: H₂O₂ 200 μM and MSM 10 μg/mL treatment; MSM 20: H₂O₂ 200 μM and MSM 200 μg/mL treatment; FJH-BS 1: H₂O₂ 200 μM and FJH-BS 1 μg/mL treatment; FJH-BS 5: H₂O₂ 200 μM and FJH-BS 5 μg/mL treatment; FJH-BS 10: H₂O₂ 200 μM and FJH-BS 10 μg/mL treatment; and FJH-BS 20: H₂O₂ 200 μM and FJH-BS 20 μg/mL treatment. Values are presented as mean + SD (n=4). Different letters (a > b > c > d > e) indicate a significant difference with p < 0.05, as determined using the Duncan’s multiple range test

Journal of Food and Nutrition Research. 2021, 9(12), 614-625 doi:10.12691/jfnr-9-12-1