Figure 1. PU prevents lipid accumulation and inhibits PA-induced cytotoxicity in HepG2 cells: (A) Crystal violet staining was used to determine the inhibitory effect of PU and/or PA in HepG2 cells. (B) HepG2 cells were treated with PA, PU or their combination for 48 h and the cell death was measured by Annexin V/PI staining of externalized phosphatidylserine in apoptotic cells. Quantitative data are presented as mean ± SD based on biological repeats. *p < 0.01 compare with control group.

From

Punicalagin Inhibits Palmitate Acid-induced Lipoapoptosis through Inhibition of ER Stress, and Activation of SIRT1/Autophagy in HepG2 Cells

Han Zhang, Hao Wu, Shutao Yin, Hongbo Hu, Chong Zhao

Journal of Food and Nutrition Research. 2020, 8(9), 536-542 doi:10.12691/jfnr-8-9-10