Figure 7. Summary of proposed actions by DHMBA on increasing mitochondrial function and FA utilization in C2C12 myotubes. DHMBA enhanced fatty acid uptake, TG storage, and mitochondrial energy metabolism in oleate-loaded C2C12 myotubes. Activation of AMPK-ACC pathway by the action of DHMBA may facilitate the transportation of FA into mitochondria for energy production. DHMBA partially dissipated proton gradient by increasing mitochondrial uncoupling, thereby increasing energy expenditure. ACC, acetyl-CoA carboxylase; AMPK, 5′-AMP-activated protein kinase; ATP, adenosine triphosphate; CPT-1, carnitine palmitoyltransferase I; ES; electrical stimulation; ETC, electron transport chain; Pi, inorganic phosphate; ROS, reactive oxygen species; TCA, tricarboxylic acid; TG, triglycerides; UCPs, mitochondrial uncoupling proteins; V, Complex V (ATP synthase)


Improvement of Mitochondrial Function and Lipid Utilization by 3,5-dihydroxy-4-methoxybenzyl Alcohol, an Oyster-derived polyphenol, in Oleate-loaded C2C12 Myotubes

Yi-Shing Ma, Shigeru Yoshida, Yu Kobayashi, Noriaki Kawanishi, Takayuki Furukawa, Hirotoshi Fuda, Shu-Ping Hui, Hitoshi Chiba

Journal of Food and Nutrition Research. 2016, 4(8), 498-507 doi:10.12691/jfnr-4-8-3