Review Article
Open Access Peer-reviewed

Reevaluating Vitamin C in Human Nutrition: Dietary Reference Intakes, Food Sources, and Supplementation Practices

Moacir C. Andrade Jr
Department of Nutrition and Metabolic Disorders, Faculty of Medicine, Instituto Metropolitano de Ensino (IME), Manaus, Brazil
Journal of Food and Nutrition Research. 2025, 13(7), 266-275. DOI: 10.12691/jfnr-13-7-5
Received June 23, 2025; Revised July 25, 2025; Accepted August 01, 2025

Abstract

Vitamin C (L-ascorbic acid) is an essential micronutrient that cannot be synthesized or stored by the human body, necessitating regular dietary intake to prevent deficiency-related conditions such as scurvy, which can be life-threatening. This review examines the pathophysiological mechanisms associated with vitamin C deficiency and evaluates current dietary reference intakes (DRIs), major dietary sources, and the role of supplementation in meeting physiological requirements. It also explores the physicochemical and molecular properties of vitamin C that affect its bioavailability, stability, and biological functions.

Keywords:

acerola, ascorbic acid, camu-camu, food composition tables, food processing and technology, kakadu plum, vitamin C toxicity
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