Acer truncatum Bunge seed oil (ASO) is rich in unsaturated fatty acids, which are recognized for their bioactive and beneficial affects on human health. We performed fatty acid profile analysis, physical and chemical detection to reveal the composition and quality of ASO in this study. We further evaluated the anti-alcohol effect of ASO, and combination with Pueraria Lobata (PL) and soybean milk (SM), in temulence rat model via animal behavioral test, including locomotor activity test, motor coordination test and step-down test. The results showed that ASO in this study was eligible and stable according to certain tests in standard, and rich in unsaturated fatty acids mainly in type of glycerolipids, and the content of nervonic acid up to 8%. We originally confirmed the content of flavonoid in ASO with content of 3.51%. ASO supplementation brought significant improvement in movement coordination, and the combination of PL and SM further enhanced the learning and memory capacity in rats. However, the combination of ASO and PL resulted adversely in motor coordination test and step-down test. In conclusion, ASO has anti-alcohol effects, which can mainly attribute to the fatty acid constituent. The pathway of ASO in anti-alcohol needs further exploration and an appreciative formula of ASO combining another ingredient is worthy development.
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