Article Versions
Export Article
Cite this article
  • Normal Style
  • MLA Style
  • APA Style
  • Chicago Style
Editorial
Open Access Peer-reviewed

Natural Plants and Cancer Therapy

Ahmed M. Kabel
Journal of Cancer Research and Treatment. 2020, 8(2), 33-34. DOI: 10.12691/jcrt-8-2-5
Received August 13, 2020; Revised September 16, 2020; Accepted September 25, 2020

Abstract

Cancer chemotherapy represents the cornerstone of management of a vast majority of neoplastic lesions. Adverse reactions of chemotherapy may affect the major body organs and represent deleterious health hazards for cancer patients. Recent studies are directed towards discovery of natural compounds of plant origin that have potential anticancer properties and may ameliorate the toxic effects induced by the traditional anticancer agents. This manuscript throws light on the potential role of the natural plants in cancer therapy.

The chemotherapeutic agents represent essential weapons for combating different types of malignancies 1. However, the adverse effects induced by these agents represent an obstacle against their role in management of cancer 2. These adverse effects depend mainly on the type of the drug itself and on the doses administered to the patients 3. To decrease the dose and toxicity and increase the efficacy of the traditional chemotherapeutic agents, different lines were investigated 2. Searching for natural agents that have potent anticancer properties may play a crucial role in amelioration of the adverse effects induced by the traditional anticancer agents 4.

The antitumor properties of a wide variety of plants had been investigated for centuries 3, 5. An example include podophyllotoxin and other compounds which were isolated from Podophyllumpeltatum and participated efficiently in the development of drugs used to treat carcinoma of the lung and testis 6. The chemopreventive effects of the natural plants were widely investigated such as the effect of Asparagus racemosa in human epidermoid carcinoma, Erthyrinasuberosa in sarcoma, Anacardiumoccidentale in hepatoma, Euphorbia hirta in Freund virus leukemia, Boswelliaserrata in human epidermal carcinoma of the nasopharynx, and Nigella sativa in lung carcinoma 7. These studies attributed the antitumor effects of these plants to their antioxidant and anti-inflammatory properties together with their ability to affect the cell cycle and induce the expression of the antiapoptotic agents 8. The main advantage of these agents is that they are nearly devoid of adverse effect which gives them an important role in management of different types of cancer 9.

Recent studies reported that natural agents may sensitize the tumor cells to the effect of the chemotherapeutic agents, decrease the drug efflux or enhance accumulation of the chemotherapeutic agents in cancer cells, and promote the mechanisms by which the normal cells can repair the damage induced by the chemotherapeutic agents 10. Using the traditional herbal medicine as a chemotherapeutic adjuvant was proven to improve the quality of life of cancer patients, ameliorate bone marrow depression, and possibly decrease the mortality rates 11. However, the occurence of herbal–drug interactions may induce toxic events that may cause liver or kidney injury that necessitate taking great caution during new drug discovery and development 2. Further studies are needed to look for herbal agents that can be used as an effective supplement for the chemotherapeutic agents to ameliorate any adverse effects and overcome resistance of cancer cells to chemotherapy.

References

[1]  Kabel AM, Omar MS, Balaha MF, Borg HM. Effect of metformin and adriamycin on transplantable tumor model. Tissue Cell 2015; 47(5): 498-505.
In article      View Article  PubMed
 
[2]  Lin SR, Chang CH, Hsu CF, et al. Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence. Br J Pharmacol 2020; 177(6): 1409-23.
In article      View Article  PubMed
 
[3]  Sultana S, Asif HM, Nazar HM, Akhtar N, Rehman JU, Rehman RU. Medicinal plants combating against cancer--a green anticancer approach. Asian Pac J Cancer Prev. 2014; 15(11): 4385-94.
In article      View Article  PubMed
 
[4]  Lichota A, Gwozdzinski K. Anticancer Activity of Natural Compounds from Plant and Marine Environment. Int J Mol Sci 2018; 19(11): 3533.
In article      View Article  PubMed
 
[5]  Kabel AM, Atef A, Estfanous RS. Ameliorative potential of sitagliptin and/or resveratrol on experimentally-induced clear cell renal cell carcinoma. Biomed Pharmacother 2018; 97: 667-74.
In article      View Article  PubMed
 
[6]  Mondal S, Bandyopadhyay S, Ghosh MK, Mukhopadhyay S, Roy S, Mandal C. Natural products: promising resources for cancer drug discovery. Anticancer Agents Med Chem 2012; 12(1): 49-75.
In article      View Article  PubMed
 
[7]  Huang CY, Ju DT, Chang CF, Muralidhar Reddy P, Velmurugan BK. A review on the effects of current chemotherapy drugs and natural agents in treating non-small cell lung cancer. Biomedicine (Taipei) 2017; 7(4): 23.
In article      View Article  PubMed
 
[8]  Qamar H, Rehman S, Chauhan DK. Current Status and Future Perspective for Research on Medicinal Plants with Anticancerous Activity and Minimum Cytotoxic Value. Curr Drug Targets 2019; 20(12): 1227-43.
In article      View Article
 
[9]  Khalifa SAM, Elias N, Farag MA, et al. Marine Natural Products: A Source of Novel Anticancer Drugs. Mar Drugs 2019; 17(9): 491.
In article      View Article  PubMed
 
[10]  Aung TN, Qu Z, Kortschak RD, Adelson DL. Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action. Int J Mol Sci 2017; 18(3): 656.
In article      View Article  PubMed
 
[11]  Fu B, Wang N, Tan HY, Li S, Cheung F, Feng Y. Multi-Component Herbal Products in the Prevention and Treatment of Chemotherapy-Associated Toxicity and Side Effects: A Review on Experimental and Clinical Evidences. Front Pharmacol 2018; 9: 1394.
In article      View Article  PubMed
 

Published with license by Science and Education Publishing, Copyright © 2020 Ahmed M. Kabel

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Cite this article:

Normal Style
Ahmed M. Kabel. Natural Plants and Cancer Therapy. Journal of Cancer Research and Treatment. Vol. 8, No. 2, 2020, pp 33-34. http://pubs.sciepub.com/jcrt/8/2/5
MLA Style
Kabel, Ahmed M.. "Natural Plants and Cancer Therapy." Journal of Cancer Research and Treatment 8.2 (2020): 33-34.
APA Style
Kabel, A. M. (2020). Natural Plants and Cancer Therapy. Journal of Cancer Research and Treatment, 8(2), 33-34.
Chicago Style
Kabel, Ahmed M.. "Natural Plants and Cancer Therapy." Journal of Cancer Research and Treatment 8, no. 2 (2020): 33-34.
Share
[1]  Kabel AM, Omar MS, Balaha MF, Borg HM. Effect of metformin and adriamycin on transplantable tumor model. Tissue Cell 2015; 47(5): 498-505.
In article      View Article  PubMed
 
[2]  Lin SR, Chang CH, Hsu CF, et al. Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence. Br J Pharmacol 2020; 177(6): 1409-23.
In article      View Article  PubMed
 
[3]  Sultana S, Asif HM, Nazar HM, Akhtar N, Rehman JU, Rehman RU. Medicinal plants combating against cancer--a green anticancer approach. Asian Pac J Cancer Prev. 2014; 15(11): 4385-94.
In article      View Article  PubMed
 
[4]  Lichota A, Gwozdzinski K. Anticancer Activity of Natural Compounds from Plant and Marine Environment. Int J Mol Sci 2018; 19(11): 3533.
In article      View Article  PubMed
 
[5]  Kabel AM, Atef A, Estfanous RS. Ameliorative potential of sitagliptin and/or resveratrol on experimentally-induced clear cell renal cell carcinoma. Biomed Pharmacother 2018; 97: 667-74.
In article      View Article  PubMed
 
[6]  Mondal S, Bandyopadhyay S, Ghosh MK, Mukhopadhyay S, Roy S, Mandal C. Natural products: promising resources for cancer drug discovery. Anticancer Agents Med Chem 2012; 12(1): 49-75.
In article      View Article  PubMed
 
[7]  Huang CY, Ju DT, Chang CF, Muralidhar Reddy P, Velmurugan BK. A review on the effects of current chemotherapy drugs and natural agents in treating non-small cell lung cancer. Biomedicine (Taipei) 2017; 7(4): 23.
In article      View Article  PubMed
 
[8]  Qamar H, Rehman S, Chauhan DK. Current Status and Future Perspective for Research on Medicinal Plants with Anticancerous Activity and Minimum Cytotoxic Value. Curr Drug Targets 2019; 20(12): 1227-43.
In article      View Article
 
[9]  Khalifa SAM, Elias N, Farag MA, et al. Marine Natural Products: A Source of Novel Anticancer Drugs. Mar Drugs 2019; 17(9): 491.
In article      View Article  PubMed
 
[10]  Aung TN, Qu Z, Kortschak RD, Adelson DL. Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action. Int J Mol Sci 2017; 18(3): 656.
In article      View Article  PubMed
 
[11]  Fu B, Wang N, Tan HY, Li S, Cheung F, Feng Y. Multi-Component Herbal Products in the Prevention and Treatment of Chemotherapy-Associated Toxicity and Side Effects: A Review on Experimental and Clinical Evidences. Front Pharmacol 2018; 9: 1394.
In article      View Article  PubMed