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Editorial
Open Access Peer-reviewed

Celiac Disease and Chronic Hepatitis C Virus Infection – Prevalence Studies

Elena Cristina Garbovan, Cornel Aldea, Genel Sur, Ciprian Silaghi, Anamaria Garbovan
International Journal of Celiac Disease. 2019, 7(2), 46-47. DOI: 10.12691/ijcd-7-2-8
Received June 26, 2019; Revised August 04, 2019; Accepted August 13, 2019

Abstract

The association of celiac disease with chronic hepatitis C virus infection was intensely debated. We aimed to study the prevalence of celiac disease in patients with chronic hepatitis C virus infection.

Association between celiac disease and chronic hepatitis C virus infection has been reported in many studies [1.2]. We want to see in this editorial the prevalence of celiac disease in patients with hepatitis C. Lindgren et al reported that celiac disease has a prevalence of 1.5% in patients with chronic liver disease, which is higher than in general, however this could be explained by the fact that celiac disease was often described as underdiagnosed 1. A study on 259 patients revealed that there is a higher prevalence of anti-gliadin antibodies in patients with liver disease such as chronic hepatitis C virus, autoimmune liver disease, and other hepatic diseases than in controls 2. Moreover, the correlation between celiac disease and chronic hepatitis C virus could consist in the silent activation of celiac disease during interferon treatment which is often unsuspected due to the fact that interferon can lead to the induction of pre-existent autoimmune disorders 3. In literature have been reported several cases of celiac disease onset during interferon therapy [4-7] 4. However, Mbbs et al published a series of four cases of celiac disease onset in patients with chronic hepatitis C virus that did not undergo interferon and ribavirin therapy 8. A study on 210 patients with chronic hepatitis C virus revealed that the prevalence of celiac disease among chronic hepatitis C virus patients is 0%, while the prevalence of chronic hepatitis C virus on 194 celiac disease patients is 1.54% comparable with the general population, furthermore there is a lack of correlations between PEG interferon-α and celiac disease 9. Ruggeri et al concluded that the prevalence of anti-endomysial antibodies in chronic hepatitis C virus patients is independent with autoimmunity 10. Another study on 120 patients with portal hypertension revealed the fact that celiac disease has a a higher prevalence in patients with cryptogenic chronic liver disease (10%) and idiopathic noncirrhotic intrahepatic portal hypertension (14%) than in hepatitis B/C-related cirrhosis (0%) 11. Studying Table 1 we can conclude that in no study the prevalence of celiac disease in chronic hepatitis C virus patients is higher than the global prevalence of chronic hepatitis C virus (2.5%) 12. The prevalence of celiac disease in chronic hepatitis C virus patients is summarized in Table 1. In conclusion, we can observe that the prevalence of celiac disease in chronic hepatitis C virus patients is decreasing over time.

Conflict of Interest

All authors contributed equally to this work.

All authors of this paper have read and approved the final version submitted.

The authors have declared that no conflict of interest exists.

Acknowledgements

`Anamaria Garbovan received a grant from the University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj–Napoca 2016, project no. 4995/21/08.03.2016.

References

[1]  Samaşca G, Burac L, Farcău D, Dejica D. Screening for celiac disease in chronic viral hepatitis C. Romanian Journal of Pediatrics 2010; 59(1): 49-50.
In article      
 
[2]  Aldea C, Sur D, Silaghi C. Hypercoagulability State in Celiac Disease and Hepatitis C Association. International Journal of Celiac Disease 2018; 6 (3): 74-751.
In article      
 
[3]  Lindgren S, Sjoberg K, Eriksson S. Unsuspected coeliac disease in chronic “cryptogenic” liver disease. Scand J Gastroenterol. 1994; 29(7): 66-4.
In article      View Article
 
[4]  Fine KD, Ogunji F, Saloum Y, Beharry S, Crippin J, Weinstein J. Celiac sprue: another autoimmune syndrome associated with hepatitis C. Am J Gastroenterol. 2001; 96(1): 138-45.
In article      View Article  PubMed
 
[5]  Durante-Mangoni E, Iardino P, Resse M, Cesaro G, Sica A, Farzati B, et al. Silent celiac disease in chronic hepatitis C: impact of interferon treatment on the disease onset and clinical outcome. J Clin Gastroenterol. 2004; 38(10): 901-5.
In article      View Article  PubMed
 
[6]  Ionita-Radu F, Bucurica S, Costache R, Nuta P, Stanciu S. An adult case with onset of celiac disease during chronic hepatitis C antiviral treatment. Rom J Intern Med. 2010; 48(1): 105-8.
In article      
 
[7]  Gombosova L, Jarcuska P, Benova B, Benicky M, Lazurova I. Celiac disease manifested during the treatment of chronic hepatitis C by pegylated alpha interferon and ribavirin. Bratisl Lek Listy. 2011; 112(6): 360-2.
In article      
 
[8]  Singh A, Zaeri N, Ho IK. Onset of Celiac Disease after Treatment of Chronic Hepatitis C with Interferon Based Triple Therapy. Case Reports in Hepatology 2015; 2015: 10-3.
In article      View Article  PubMed  PubMed
 
[9]  Vasudevan A, Lubel JS. Case report New-onset of celiac disease during interferon-based therapy for hepatitis C. Gastroenterol Rep (Oxf). 2015; 3(1): 83-5.
In article      View Article  PubMed  PubMed
 
[10]  Mbbs AG, Dm CR, Duseja A, Facg DM, Chawla Y, Fams DM. Association between Celiac Disease and Chronic Hepatitis C. J Clin Exp Hepatol 2011; 1(1): 41-4.
In article      View Article
 
[11]  Gravina AG, Federico A, Masarone M, Cuomo A, Tuccillo C, Loguercio C, et al. Coeliac disease and C virus-related chronic hepatitis: a non association. BMC Res Notes. 2012; 5: 533.
In article      View Article  PubMed  PubMed
 
[12]  Ruggeri C, La Masa AT, Rudi S, Squadrito G, Di Pasquale G, Maimone S, et al. Celiac disease and non-organ-specific autoantibodies in patients with chronic hepatitis C virus infection. Dig Dis Sci. 2008; 53(8): 2151-5.
In article      View Article  PubMed
 
[13]  Maiwall R, Goel A, Pulimood AB, Babji S, Sophia J, Prasad C, Balasubramanian KA, Ramakrishna B, Kurian S, Fletcher GJ, Abraham P, Kang G, Ramakrishna BS, Elias E, Eapen CE.Investigation into celiac disease in Indian patients with portal hypertension. Indian J Gastroenterol. 2014; 33(6): 517-23.
In article      View Article  PubMed
 
[14]  Petruzziello A, Marigliano S, Loquercio G, Cozzolino A, Cacciapuoti C. Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes. World J Gastroenterol. 2016; 22(34): 7824-40.
In article      View Article  PubMed  PubMed
 
[15]  Villalta D, Girolami D, Bidoli E, Bizzaro N, Tampoia M, Liguori M, et al. High Prevalence of Celiac Disease in Autoimmune Hepatitis Detected by Anti-Tissue Tranglutaminase Autoantibodies. J Clin Lab Anal. 2005; 10(2004): 6-10.
In article      View Article  PubMed
 
[16]  Thevenot T, Denis J, Jouannaud V, Monnet E, Renou C, Labadie H, et al. Coeliac disease in chronic hepatitis C: a French multicentre prospective study. Aliment Pharmacol Ther. 2007; 26(9): 1209-16.
In article      View Article  PubMed
 
[17]  Hernandez L, Johnson TC, Naiyer AJ, Kryszak D, Ciaccio EJ, Min A, et al. Chronic hepatitis C virus and celiac disease, is there an association? Dig Dis Sci. 2008; 53(1): 256-61.
In article      View Article  PubMed
 
[18]  Sarmiento L, Galvan A, Cabrera-rode E, Aira L, Sarmiento L, Correa C, Sariego S, et al. Type 1 Diabetes Associated and Tissue Transglutaminase Autoantibodies in Patients Without Type 1 Diabetes and Coeliac Disease With Confirmed Viral Infections. J Med Virol. 2012; 84(7): 1049-53.
In article      View Article  PubMed
 
[19]  Gravina AG, Federico A, Masarone M, Cuomo A, Tuccillo C, Loguercio C, et al. Coeliac disease and C virus-related chronic hepatitis: a non association. BMC Res Notes. 2012; 5: 533.
In article      View Article  PubMed  PubMed
 
[20]  Marconcini ML, Fayad L, Shiozawa MBC, Dantas-Correa EB, Lucca Schiavon L de, Narciso-Schiavon JL. Autoantibody profile in individuals with chronic hepatitis C. Rev Soc Bras Med Trop. 2013; 46(2): 147-53.
In article      View Article  PubMed
 

Published with license by Science and Education Publishing, Copyright © 2019 Elena Cristina Garbovan, Cornel Aldea, Genel Sur, Ciprian Silaghi and Anamaria Garbovan

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Cite this article:

Normal Style
Elena Cristina Garbovan, Cornel Aldea, Genel Sur, Ciprian Silaghi, Anamaria Garbovan. Celiac Disease and Chronic Hepatitis C Virus Infection – Prevalence Studies. International Journal of Celiac Disease. Vol. 7, No. 2, 2019, pp 46-47. http://pubs.sciepub.com/ijcd/7/2/8
MLA Style
Garbovan, Elena Cristina, et al. "Celiac Disease and Chronic Hepatitis C Virus Infection – Prevalence Studies." International Journal of Celiac Disease 7.2 (2019): 46-47.
APA Style
Garbovan, E. C. , Aldea, C. , Sur, G. , Silaghi, C. , & Garbovan, A. (2019). Celiac Disease and Chronic Hepatitis C Virus Infection – Prevalence Studies. International Journal of Celiac Disease, 7(2), 46-47.
Chicago Style
Garbovan, Elena Cristina, Cornel Aldea, Genel Sur, Ciprian Silaghi, and Anamaria Garbovan. "Celiac Disease and Chronic Hepatitis C Virus Infection – Prevalence Studies." International Journal of Celiac Disease 7, no. 2 (2019): 46-47.
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[1]  Samaşca G, Burac L, Farcău D, Dejica D. Screening for celiac disease in chronic viral hepatitis C. Romanian Journal of Pediatrics 2010; 59(1): 49-50.
In article      
 
[2]  Aldea C, Sur D, Silaghi C. Hypercoagulability State in Celiac Disease and Hepatitis C Association. International Journal of Celiac Disease 2018; 6 (3): 74-751.
In article      
 
[3]  Lindgren S, Sjoberg K, Eriksson S. Unsuspected coeliac disease in chronic “cryptogenic” liver disease. Scand J Gastroenterol. 1994; 29(7): 66-4.
In article      View Article
 
[4]  Fine KD, Ogunji F, Saloum Y, Beharry S, Crippin J, Weinstein J. Celiac sprue: another autoimmune syndrome associated with hepatitis C. Am J Gastroenterol. 2001; 96(1): 138-45.
In article      View Article  PubMed
 
[5]  Durante-Mangoni E, Iardino P, Resse M, Cesaro G, Sica A, Farzati B, et al. Silent celiac disease in chronic hepatitis C: impact of interferon treatment on the disease onset and clinical outcome. J Clin Gastroenterol. 2004; 38(10): 901-5.
In article      View Article  PubMed
 
[6]  Ionita-Radu F, Bucurica S, Costache R, Nuta P, Stanciu S. An adult case with onset of celiac disease during chronic hepatitis C antiviral treatment. Rom J Intern Med. 2010; 48(1): 105-8.
In article      
 
[7]  Gombosova L, Jarcuska P, Benova B, Benicky M, Lazurova I. Celiac disease manifested during the treatment of chronic hepatitis C by pegylated alpha interferon and ribavirin. Bratisl Lek Listy. 2011; 112(6): 360-2.
In article      
 
[8]  Singh A, Zaeri N, Ho IK. Onset of Celiac Disease after Treatment of Chronic Hepatitis C with Interferon Based Triple Therapy. Case Reports in Hepatology 2015; 2015: 10-3.
In article      View Article  PubMed  PubMed
 
[9]  Vasudevan A, Lubel JS. Case report New-onset of celiac disease during interferon-based therapy for hepatitis C. Gastroenterol Rep (Oxf). 2015; 3(1): 83-5.
In article      View Article  PubMed  PubMed
 
[10]  Mbbs AG, Dm CR, Duseja A, Facg DM, Chawla Y, Fams DM. Association between Celiac Disease and Chronic Hepatitis C. J Clin Exp Hepatol 2011; 1(1): 41-4.
In article      View Article
 
[11]  Gravina AG, Federico A, Masarone M, Cuomo A, Tuccillo C, Loguercio C, et al. Coeliac disease and C virus-related chronic hepatitis: a non association. BMC Res Notes. 2012; 5: 533.
In article      View Article  PubMed  PubMed
 
[12]  Ruggeri C, La Masa AT, Rudi S, Squadrito G, Di Pasquale G, Maimone S, et al. Celiac disease and non-organ-specific autoantibodies in patients with chronic hepatitis C virus infection. Dig Dis Sci. 2008; 53(8): 2151-5.
In article      View Article  PubMed
 
[13]  Maiwall R, Goel A, Pulimood AB, Babji S, Sophia J, Prasad C, Balasubramanian KA, Ramakrishna B, Kurian S, Fletcher GJ, Abraham P, Kang G, Ramakrishna BS, Elias E, Eapen CE.Investigation into celiac disease in Indian patients with portal hypertension. Indian J Gastroenterol. 2014; 33(6): 517-23.
In article      View Article  PubMed
 
[14]  Petruzziello A, Marigliano S, Loquercio G, Cozzolino A, Cacciapuoti C. Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes. World J Gastroenterol. 2016; 22(34): 7824-40.
In article      View Article  PubMed  PubMed
 
[15]  Villalta D, Girolami D, Bidoli E, Bizzaro N, Tampoia M, Liguori M, et al. High Prevalence of Celiac Disease in Autoimmune Hepatitis Detected by Anti-Tissue Tranglutaminase Autoantibodies. J Clin Lab Anal. 2005; 10(2004): 6-10.
In article      View Article  PubMed
 
[16]  Thevenot T, Denis J, Jouannaud V, Monnet E, Renou C, Labadie H, et al. Coeliac disease in chronic hepatitis C: a French multicentre prospective study. Aliment Pharmacol Ther. 2007; 26(9): 1209-16.
In article      View Article  PubMed
 
[17]  Hernandez L, Johnson TC, Naiyer AJ, Kryszak D, Ciaccio EJ, Min A, et al. Chronic hepatitis C virus and celiac disease, is there an association? Dig Dis Sci. 2008; 53(1): 256-61.
In article      View Article  PubMed
 
[18]  Sarmiento L, Galvan A, Cabrera-rode E, Aira L, Sarmiento L, Correa C, Sariego S, et al. Type 1 Diabetes Associated and Tissue Transglutaminase Autoantibodies in Patients Without Type 1 Diabetes and Coeliac Disease With Confirmed Viral Infections. J Med Virol. 2012; 84(7): 1049-53.
In article      View Article  PubMed
 
[19]  Gravina AG, Federico A, Masarone M, Cuomo A, Tuccillo C, Loguercio C, et al. Coeliac disease and C virus-related chronic hepatitis: a non association. BMC Res Notes. 2012; 5: 533.
In article      View Article  PubMed  PubMed
 
[20]  Marconcini ML, Fayad L, Shiozawa MBC, Dantas-Correa EB, Lucca Schiavon L de, Narciso-Schiavon JL. Autoantibody profile in individuals with chronic hepatitis C. Rev Soc Bras Med Trop. 2013; 46(2): 147-53.
In article      View Article  PubMed