Figure 5. Growth and cell proliferation of A549 cells after 10-day treatment. Representative images of randomly selected microscopic fields of the colonies formed after 10 consecutive days exposure to increasing concentrations (0.05 - 10 μg/ml) of Cd-SiNPs (a), CdCl₂ (b) and SiNPs (c). The formation of A549 colonies appears to be serious compromised by Cd-SiNP or CdCl₂ treatments, few colonies with reduced size compared to control were observed at the lower concentrations (0.05 - 10 μg/ml) of Cd-SiNPs and CdCl₂, while there was a total inhibition of the colonies at the higher tested doses (25 - 100 μg/ml) for both Cd-SiNPs and CdCl₂. (Scale bar: 600 μm). SiNP colonies showed similar patterns at the all tested doses to the control. Quantitative analysis of the colony number is shown for each treatment. Histograms show the number of colonies formed after 10 consecutive days Data are mean ± SD of three separate experiments. *Different from control 𝑃 < 0.05, Statistical analysis by ANOVA. Error bars: ± SD

From

An integrated in Vitro and in Vivo Testing Approach to Assess Pulmonary Toxicity of Engineered Cadmium-Doped Silica Nanoparticles

Uliana De Simone, Elisa Roda, Cinzia Signorini, Teresa Coccini

• Previous
• Figure 5 of 10  (Figures index)
• Next