Figure 4. Intracellular GSH content in A549 cells after 1-day treatment. Glutathione measurement in A549 cells unexposed (control) and exposed to increasing concentrations (10 - 100 μg/ml) of Cd-SiNPs, CdCl₂, SiNPs after 24 h. GSH levels were affected by all tested materials. Data are mean ± SD of three separate experiments each carried out in six replicates. *Different from control 𝑃 < 0.05, Statistical analysis by ANOVA

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An integrated in Vitro and in Vivo Testing Approach to Assess Pulmonary Toxicity of Engineered Cadmium-Doped Silica Nanoparticles

Uliana De Simone, Elisa Roda, Cinzia Signorini, Teresa Coccini

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