Figure 2. Synthesis routes of sulfone derivatives containing 1,3,4-oxadiazole moiety. Reaction conditions and reagents: (a) MeOH, 98%H₂SO₄, reflux 5h; (b) NH₂NH₂▪H₂O, EtOH, 25°C–reflux, 4h; (c) KOH, CS₂, EtOH, 25-46-76°C, 7h; (d) NaOH, H₂O, dimethyl(diethyl) sulfate or halide (RX), rt 4 h, 90%; (e) KMnO₄, AcOH, rt, 1 h

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Synthesis and Biological Evaluation of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole Moiety

Shihu Su, Xia Zhou, Yan Zhou, Guoping Liao, Li Shi, Xia Yang, Xian Zhang, Linhong Jin

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