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From

Synthesis and Biological Evaluation of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole Moiety

Shihu Su, Xia Zhou, Yan Zhou, Guoping Liao, Li Shi, Xia Yang, Xian Zhang, Linhong Jin

World Journal of Organic Chemistry. 2014, 2(1), 18-27 doi:10.12691/wjoc-2-1-3
  • Figure 1. Compounds strunture
  • Figure 2. Synthesis routes of sulfone derivatives containing 1,3,4-oxadiazole moiety. Reaction conditions and reagents: (a) MeOH, 98%H2SO4, reflux 5h; (b) NH2NH2▪H2O, EtOH, 25°C–reflux, 4h; (c) KOH, CS2, EtOH, 25-46-76°C, 7h; (d) NaOH, H2O, dimethyl(diethyl) sulfate or halide (RX), rt 4 h, 90%; (e) KMnO4, AcOH, rt, 1 h
  • Figure 3. Synthesis routes of sulfone derivatives containing phenoxymethyl and 1,3,4-oxadiazole moiety. Reaction conditions and reagents: (a) MeOH, 98%H2SO4, reflux 5h; (b) NH2NH2▪H2O, EtOH, 25°C–reflux, 1h; (c)KOH, CS2, EtOH, 25-46-76°C, 7h; (d) NaOH, H2O, dimethyl(diethyl) sulfate or halide (RX), rt 4 h, 90%; (e) KMnO4, AcOH, rt, 1 h