Figures index

From

The Analgesic Metamizole (Dipyrone) and Its Related Products Antipyrine, 4-Aminoantipyrine and 4-Methylaminoantipyrine. Part 1: Mass Spectrometric and Electrochemical Detection

Achim Habekost

World Journal of Chemical Education. 2018, 6(3), 134-144 doi:10.12691/wjce-6-3-6
  • Figure 1. UV spectra of antipyrine (top left), 4-aminoantipyrine (top right), methylaminoantipyrine (bottom left) and metamizole (bottom right). See also Table 1
  • Figure 2. EI-mass spectra. a) antipyrine;b): 4-aminoantipyrine; c) methylaminoantipyrine; d) metamizole (dimethylaminoantipyrine)
  • Figure 3. GC-MS of a mixture of aminoantipyrine, methylaminoantipyrine and metamizole. The substance at about 14 min could not be identified
  • Figure 4. EI-MS of the substance at the 14-min retention time
  • Figure 5. Concentration dependence of dimethylaminoantipyrine, the thermal decomposition product of metamizole, in the range of 55 μmol/L–500 μmol/L. Insert: 55 μmol/L–100 μmol/L
  • Figure 6. Concentration dependence of dimethylaminoantipyrine. The curve shows a linear dependence between 55 and 500 μmol/L
  • Figure 7. SEM of the Au SPE (kindly from DropSens)
  • Figure 8. Cyclic voltammogram (CV) of metamizole with gold as the working electrode
  • Figure 9. CV of metamizole with different voltage ranges
  • Figure 10. CVs of the four antipyrine derivates at pH 10. Thick line: metamizole; thin line: antipyrine; dotted line: 4-aminoantipyrine; dashed line: methylaminoantipyrine
  • Figure 11. Cyclic voltammograms and electrogenerates curves. Solid lines: cyclic voltammograms; dotted lines: ECL of [Ru(bpy)3]2+ / proline with (concentrations from 1 mmol, 0.5 mmol and 0.1 mmol (1→3)) and without (4) metamizole. Working electrode: Au 220 AT
  • Figure 12. Amperometric detection of metamizole at pH 10. Injection volume: 10 μL. Three different concentrations—1 mmol/L, 90 μmol/L and 8 μmol/L—injected three times. LOD = 8*10-11 mol = 25 ng