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2 Result(s) for 'Srinivas Kolla'
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1.
Fluoroquinolone-Induced Rotator Cuff Tendinopathy: A Case Report
Hussam Alkaissi, Srinivas Kolla , Cameron Page, Latif Salam, Moro O. Salifu, Isabel M. McFarlane
American Journal of Medical Case Reports. 2021 9 (2). doi: 10.12691/ajmcr-9-2-6
Keywords: fluoroquinolone, tendinopathy, rotator cuff
Context: Fluoroquinolones are antimicrobial agents that inhibit bacterial DNA synthesis by binding to DNA gyrase and DNA topoisomerase IV. Fluoroquinolones have also been associated with the development of tendinopathy, tendon rupture, and arthropathy. The postulated mechanisms for quinolone-associated tendinopathy are alteration of the tendon extracellular matrix, impairment of tenocyte proliferation, and enhanced apoptosis due to the quinolone cation chelation properties. We present a case of a man who developed multiple tears of the rotator cuff after exposure to levofloxacin. Although marketed quinolones are well tolerated, adverse events involving gastrointestinal, cardiovascular, neurological, and tendinopathy and at-risk patient populations should be kept in mind by clinicians.
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2.
Refractory Effusions, Crumbly Bones, Mystifying Cachexia and an Absent Mind: An Unusual Presentation of Whipple’s Disease with Review of Literature
Syed Hamza Bin Waqar, John Diks, Unaiza Zaman, Sarah Sharif, Taha Sheikh, Srinivas Kolla , Isabel M. McFarlane
American Journal of Medical Case Reports. 2021 9 (7). doi: 10.12691/ajmcr-9-7-2
Keywords: Whipple’s disease, Tropheryma whipplei, malabsorption, protein-losing enteropathy
Context: Whipple’s disease is a bacterial infection caused by Tropheryma whipplei and is known to cause perplexing clinical presentations, making its diagnosis challenging. The beginning by the involvement of the gastrointestinal tract, Whipple's disease can slowly progress to affect almost any organ system and lead to chronic multi-system inflammatory disease. Hereby, we present a middle age man who initially manifested with shortness of breath and chronic weight loss. He subsequently developed pleuro-pericardial effusion, ascites, mesenteric lymphadenopathy, possible myocarditis, and severe osteopenia with multiple vertebral fractures during his illness. Esophagogastroduodenoscopy with the biopsy and subsequent molecular confirmation of disease led to the confirmation of WD. Therapeutic management included two separate antibiotic regimens in an attempt to address the refractory course of WD in this patient.
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