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Model Drug Release from Potato Starch-Starch Glycolate Microparticles and Films with and without Incorporated Nano-SiO2

Fateh Eltaboni, Amira Alhodeary, Mona Ibrahim, Fawzia Ali, Aya Al Abdali, Nadin Al Farsi, Fatma Elshibani, Mohamed Ali Sharkasi

Journal of Polymer and Biopolymer Physics Chemistry. 2020, 8(1), 15-27 doi:10.12691/jpbpc-8-1-2
  • Figure 1. Standard curve for PSS solutions using absorbance at 600 nm (a). Kinetics for experimental data of starch yield per one gram of potato (dots) a combined with a mathematical fitting, plateau followed by one phase decay (solid lines)
  • Figure 2. A plot of Hc/ versus the concentration of PSS, PSE, and SSG polymers (R2 for PSS = 0.9496, for PSE R2= 0.9951, and for SSG R2 = 0.9970)
  • Figure 3. Absorption spectra, opacity (blue bars), and UV-barrier capacity (red bars) of potato starch soluble film (PSS), PSS with silica film (PSS-Si), PSS with 0.1 % of starch glycolate film (PSS-SSG0.1%), PSS with 1 % of starch glycolate film (PSS-SSG1%), PSS with silica and 0.1 % of starch glycolate film (PSS-Si-SSG0.1%), and PSS with silica and 1 % of starch glycolate film (PSS-Si-SSG1%)
  • Figure 4. Densities (film x 10-3 g cm-3), swellings (S) and folding endurance (folds) of PSS film and its composites
  • Figure 5. Visual aspect of selected films obtained from starch
  • Figure 6. UV-vis absorption scan in a range equal to 350-650 nm for crystal violet (12.5 M in chloroform) at 37°C
  • Figure 7. Release profiles of crystal violet from PSE-Si-CV film, PSE-Si-CV-SSG1% film, PSE-CV mixture and PSE-CV-SSG1% mixture in phosphate buffer solution (PBS) pH 7.4 at 37°C
  • Scheme 1. Schematic representation of drug release from non swellable film-diffusion (a) and from a film made of swellable polymer (b). The phenomena of water uptake, swelling, polymer chain relaxation, drug diffusion, polymer chain disentanglement, and polymer edibility are depicted
  • Figure 8. Zero order (a), first order (b), Higuchi model, (c), and Korsmeyer-Peppas model (d) kinetics release of CV from PSE-Si-CV and PSE-Si-CV-SSG1% films in phosphate buffer solution (PBS) pH 7.4 at 37°C