Figure 4. Probable transformation reaction of heme-artemisinin adducts with A the structure of the alkylated heme by an artemisinin group in position β (β adduct) and B a probable structure of alkylated heme having in one of its meso positions a less bulky group

From

Plasmodium Resistance to Antimalarial Drugs: Functional Theory of Density (DFT) Study of the Stability and Reactivity of Heme-Artemisinin Adducts

Affoué Lucie Bédé, Amon Benjamine Assoma, El Hadji Sawaliho Bamba, Maftei Dan, Ionel Humelnicu

Journal of Materials Physics and Chemistry. 2018, 6(1), 17-22 doi:10.12691/jmpc-6-1-3