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From
Histopathological Examination of the Effects of Oral Consumption of Various Doses of Propolis in Mice Liver
Fatemeh Samiee-Rad, Sadaf Bagherkhani, Nematollahe Gheibi
Journal of Food and Nutrition Research
.
2019
, 7(11), 785-793 doi:10.12691/jfnr-7-11-5
Figure 1.
The histopathologic findings of control group. Liver lobule including hepatocytes and associated with portal tract. Magnification x400, Hematoxylin and Eosin
Full size figure and legend
Figure 2.
The different histopathologic changes of mice liver , sham group. Hyperemia(M), increase of Kupffer cells(M).(Mild:M,). Magnification x400, Hematoxylin and Eosin
Full size figure and legend
Figure 3.
The different histopathologic changes of mice liver received propolis extract at concentrations of 2000 mg/ kg.
A
: Hyperemia(Mo), ductular reaction (M).
B
: Central vein dilation(Mo), hyperemia(Mo), increase of Kupffer cells(M), sinusoidal inflammatory cells infiltrating (M), cholestasis (M to Mo), focal necroinflammation(M to Mo).
C
: Central vein dilation(Mo), hyperemia, cholestasis(M to Mo), feathery change (M to Mo).
D
: Apoptosis (M to Mo)(arrow), hyperemia(Mo), cholestasis(M to Mo), feathery change (M to Mo).
E
: Hyperemia (Mo), cholestasis(M to Mo), feathery change (M to Mo), increase of Kupffer cells(M), sinusoidal inflammatory cells infiltrating (M), portal inflammation(M).
F
: Cholestasis(M to Mo), feathery change(M to Mo), steatosis (M).
G
: Portal inflammation (M), Periportal interface hepatitis (M), increase of Kupffer cells(M), sinusoidal inflammatory cells infiltrating (M). (Mild:M, Moderate:Mo,Mild to moderate: M to Mo). Magnification x400, Hematoxylin and Eosin
Full size figure and legend
Figure 4
A-H
.
The different histopathologic changes of mice liver received propolis extract at concentrations of 4000 mg/ kg.
A
: Hyperemia(Mo), central vein dilation(Mo), cholestasis(M to Mo), feathery change(Mo).
B
: Hyperemia(Mo to Se), increase of Kupffer cells(M to Mo), sinusoidal inflammatory cells infiltrating(M), cholestasis(M to Mo), multiple focal necroinflammation(Mo).
C
: Hyperemia(Mo), cholestasis(M to Mo), feathery change(Mo), multiple apoptosis(Mo) ( arrow), increase of Kupffer cells(M to Mo), sinusoidal inflammatory cells infiltrating(M).
D
: Hyperemia(Mo), cholestasis(M to Mo), feathery change(Mo), increase of Kupffer cells(M to Mo), steatosis(M).
E
: Hyperemia(Mo), cholestasis(M to Mo), feathery change(Mo), multiple focal necroinflammation(Mo) and apoptosis(arrows).
F
: Hyperemia(Mo), cholestasis(M to Mo), feathery change(Mo), increase of Kupffer cells(M to Mo), sinusoidal inflammatory cells infiltrating(M), focal necroinflammation(Mo).
G
: Hyperemia(Mo), cholestasis(M to Mo), feathery change(Mo), increase of Kupffer cells(M to Mo), sinusoidal inflammatory cells infiltrating(M), periportal interface hepatitis(M), multiple apoptosis(Mo)(arrows). H: Hyperemia(Mo), cholestasis(M to Mo), feathery change(Mo), increase of Kupffer cells(M to Mo), sinusoidal inflammatory cells infiltrating(M), focal necroinflammation(Mo).
Full size figure and legend
Figure 4
I
.
The different histopathologic changes of mice liver received propolis extract at concentrations of 4000 mg/ kg.
I
: Ductular reaction (M to Mo). (Mild:M, Moderate: Mo, Mild to moderate: M to Mo, Moderate to Severe: Mo to Se). Magnification x400, Hematoxylin and Eosin
Full size figure and legend
Figure 5
A-
F
.
The different histopathologic changes of mice liver received propolis extract at concentrations of 8000 mg/ kg.
A
: Hyperemia(Mo), cholestasis(Mo), feathery change(Mo).
B
: Hyperemia(Mo), cholestasis(Mo), feathery change(Mo), increase of Kupffer cells(M), sinusoidal inflammatory cells infiltrating(M), focal necroinflammation(Mo).
C
: Cholestasis(Mo), feathery change(Mo), periportal interface hepatitis(M), confluent necrosis(M), Portal inflammation(M).
D
: Hyperemia(Mo), cholestasis(Mo), feathery change(Mo), increase of Kupffer cells(M), apoptosis (Mo) (arrow), focal necroinflammation(Mo).
E
: Hyperemia(Mo), cholestasis(Mo), feathery change(Mo), steatosis(Mo).
F
: Hyperemia(Mo), cholestasis(Mo), feathery change(Mo), ), increase of Kupffer cells(M), sinusoidal inflammatory cells infiltrating(M), focal necroinflammation(Mo)
Full size figure and legend
Figure 5
G
. The different histopathologic changes of mice liver received propolis extract at concentrations of 8000 mg/ kg.
G
: Hyperemia(Mo), cholestasis(Mo), feathery change(Mo), ductular reaction(M). (Mild:M, Moderate:Mo). Magnification x400, Hematoxylin and Eosin
Full size figure and legend