Figure 4A-H. The different histopathologic changes of mice liver received propolis extract at concentrations of 4000 mg/ kg. A: Hyperemia(Mo), central vein dilation(Mo), cholestasis(M to Mo), feathery change(Mo). B: Hyperemia(Mo to Se), increase of Kupffer cells(M to Mo), sinusoidal inflammatory cells infiltrating(M), cholestasis(M to Mo), multiple focal necroinflammation(Mo). C: Hyperemia(Mo), cholestasis(M to Mo), feathery change(Mo), multiple apoptosis(Mo) ( arrow), increase of Kupffer cells(M to Mo), sinusoidal inflammatory cells infiltrating(M). D: Hyperemia(Mo), cholestasis(M to Mo), feathery change(Mo), increase of Kupffer cells(M to Mo), steatosis(M). E: Hyperemia(Mo), cholestasis(M to Mo), feathery change(Mo), multiple focal necroinflammation(Mo) and apoptosis(arrows). F: Hyperemia(Mo), cholestasis(M to Mo), feathery change(Mo), increase of Kupffer cells(M to Mo), sinusoidal inflammatory cells infiltrating(M), focal necroinflammation(Mo). G: Hyperemia(Mo), cholestasis(M to Mo), feathery change(Mo), increase of Kupffer cells(M to Mo), sinusoidal inflammatory cells infiltrating(M), periportal interface hepatitis(M), multiple apoptosis(Mo)(arrows). H: Hyperemia(Mo), cholestasis(M to Mo), feathery change(Mo), increase of Kupffer cells(M to Mo), sinusoidal inflammatory cells infiltrating(M), focal necroinflammation(Mo).

From

Histopathological Examination of the Effects of Oral Consumption of Various Doses of Propolis in Mice Liver

Fatemeh Samiee-Rad, Sadaf Bagherkhani, Nematollahe Gheibi

Journal of Food and Nutrition Research. 2019, 7(11), 785-793 doi:10.12691/jfnr-7-11-5