Figure 3. The different histopathologic changes of mice liver received propolis extract at concentrations of 2000 mg/ kg. A: Hyperemia(Mo), ductular reaction (M). B: Central vein dilation(Mo), hyperemia(Mo), increase of Kupffer cells(M), sinusoidal inflammatory cells infiltrating (M), cholestasis (M to Mo), focal necroinflammation(M to Mo). C: Central vein dilation(Mo), hyperemia, cholestasis(M to Mo), feathery change (M to Mo). D: Apoptosis (M to Mo)(arrow), hyperemia(Mo), cholestasis(M to Mo), feathery change (M to Mo). E: Hyperemia (Mo), cholestasis(M to Mo), feathery change (M to Mo), increase of Kupffer cells(M), sinusoidal inflammatory cells infiltrating (M), portal inflammation(M). F: Cholestasis(M to Mo), feathery change(M to Mo), steatosis (M). G: Portal inflammation (M), Periportal interface hepatitis (M), increase of Kupffer cells(M), sinusoidal inflammatory cells infiltrating (M). (Mild:M, Moderate:Mo,Mild to moderate: M to Mo). Magnification x400, Hematoxylin and Eosin

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Histopathological Examination of the Effects of Oral Consumption of Various Doses of Propolis in Mice Liver

Fatemeh Samiee-Rad, Sadaf Bagherkhani, Nematollahe Gheibi

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