Figure 4. Inhibitory effects of CFE administration on production of PGE₂, TNF-α, IL-1β, and IL-6 in Raw264.7 cells. Raw264.7 cells (1.0×10⁶ cells/mL) were pre-incubated for 2 h with F. erecta CH₂Cl₂ fractions (CFE; 0, 25, 50, and 100 µg/mL). Cells were stimulated with LPS (1 μg/mL) for 24 h. LPS-induced production/release of PGE₂ (A), TNF-α (B), IL-1β (C), and IL-6 (D) were determined by ELISA. Data are mean ± standard deviation (SD). The value of the LPS alone group was set at 1, and results were expressed as a ratio relative to the LPS alone group. ^*P<0.05 and ^**P<0.01 (test fraction vs. the LPS alone group). LPS, lipopolysaccharide; PGE₂, prostaglandin E₂; TNF-α, tumor necrosis factor-α; IL-1β, interleukin-1β; IL-6, interleukin-6

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The CH₂Cl₂ Extract Fraction from Ficus erecta var. sieboldii (Miq.) King Suppresses Lipopolysaccharide-mediated Inflammatory Responses in Raw264.7 Cells

Young-Min Ham, Weon-Jong Yoon, Eun Hwa Sohn, Dae Won Park, Hyelin Jeon, Yong-Hwan Jung, Sung Ryul Lee, Se Chan Kang

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