Figure 3. Effect of CO-EtOH on hepatic glucose metabolism-related genes and glucose uptake in L6 myotubes. Sprague-Dawley rats were orally administered CO-EtOH (760 mg/kg body weight) or CMC daily. The expression of GLUT2 (A), GK (B) PEPCK and G6Pase (C) was evaluated by RT-qPCR. Values are expressed as mean ± SEM (n = 8-10). (D) L6 myotubes were incubated with palmitic acid for 14 hours to induce insulin resistance, followed by 1 mg/mL CO-EtOH for 0.5 hour. Thirty-minute treatment of 100 nM insulin was used as a positive control. Statistical significance was analyzed by ANOVA and then by LSD multiple range test. Note: p < 0.05 was considered statistically significant. In animal model: *indicates statistical difference between DC group and NC group. ^#indicates statistical difference between DC + CO-EtOH group and DC group. In cellular model: *indicates statistical difference between insulin or palmitic acid group and control group. ^#indicates statistical difference between palmitic acid + CO-EtOH group and palmitic acid group

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Study on Mechanisms Underlying the Preventive Effects of Canarium album L. ethanol Extract on Modulation of Hyperglycemia and Hypercholesterolemia in Diabetic Rats

Yu-Han Kao, Yu-Te Yeh, An-Na Chiang, Shu-Chen Hsieh

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