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From

Identification of Extracts from “one Steaming and one Sun-drying” Black Panax quinquefolius and Mechanism of Majoroside F6 in Inhibiting Breast Cancer Cell

Rui Ma, Hantian Guo, Mengqing Guo, Shen Li, Liwen Tang, Yao Sun

Journal of Food and Nutrition Research. 2024, 12(10), 446-460 doi:10.12691/jfnr-12-10-7
  • Figure 1. Base peak ion chromatography of BPQ in and negative modes
  • Figure 2. The Disease-Drug-Pathway-Targets Network (a) and Visualize the PPI network through Cytoscape 3.9.1 (b)
  • Figure 3. Analysis of GO and KEGG enrichment. (a)Top 10 GO terms (p < 0.05) in the biological process (BP), cellular component (CC) and molecular function (MF) categories. (b) Top 10 KEGG pathways (p < 0.05)
  • Figure 4. The molecular docking modes of majoroside F6 and (a)EGFR, (b)STAT3, (c)HSP90AA1, (d)AKT1, (e) SRC
  • Figure 5. HSCCC of the BPQRS fraction (a), HPLC analysis of HSCCC peak fraction: Peak 1 (b), Peak 2 (c) and ESI-MS/MS spectra of the separated peak fractions on HSCCC: Peak 1，majoroside F6 (d); Peak 2, ginsenoside Rk1 (e)
  • Figure 6. MTT assay for determining cytotoxicity of MCF7 cells (a) and HEK-293 cells (b).Significance levels: ** p < 0.01, * p < 0.05 compared to the control (0 μg/mL PBP). Typical morphological changes in MCF7 cells and flow cytometry analysis and annexin V-FITC staining were used to evaluate apoptosis in HCT 116 cells. Control(c), 20μg/mL(d), 60 μg/mL(e) and 80 μg/mL(f)(n = 3 per group, repeated 5 times). Histograms of the apoptotic rates (g). Significance levels: ** p < 0.01, * p < 0.05 compared to the control (0 μg/mL majoroside F6)
  • Figure 7. The effect of majoroside F6 on the content of (a)PI3K, (b)AKT, (c)Caspase3, (d)Bax and (e)Blc-2 in everolimus-induced MCF7 cells. Significance levels:** p < 0.01, * p < 0.05 compared to the control (0 μg/mL majoroside F6)