Figures index

From

Orlistat and Hydroxycitrate Ameliorate Colon Cancer in Rats: The Impact of Inflammatory Mediators

Hesham Fathy Hassan Hassan, Ahmed Mohamed Mansour, El-Sayed Mohamed El-Sayed

Journal of Food and Nutrition Research. 2022, 10(1), 41-49 doi:10.12691/jfnr-10-1-6
  • Figure 1.1. Histology of colon of the control (saline), DMH group, HFD group, DMH+HFD group. (A) Control: colonic wall show glands lined by tall columnar mucous-secreting epithelial cells (black arrow); (B) DMH group: colonic wall showed glands lined by epithelial cells with loss of mucous secretion (black arrow), focal nuclear stratification with prominent nucleoli (yellow arrow), and few mitotic figures (blue arrow), ACF; adenoma with moderate to severe dysplasia; (C) HFD group: colonic wall showing glands with reduction of mucous secretion of epithelial lining with focal nuclear stratification (black arrow) and prominent nucleoli (yellow arrow), and scattered mitotic figures (blue arrow), ACF; adenoma with mild to moderate dysplasia; (D) DMH/HFD group: colonic wall showing glands lined by epithelial cells with reduction of mucous secretion and elongated nuclei (red arrow), frequent mitotic figures (yellow arrow), mildly edematous interstitium (black arrow), and markedly dilated congested blood vessels (blue arrow), ACF; adenoma with moderate to severe dysplasia
  • Figure 1.2. Histology of colon samples of the orlistat group, orlistat/DMH group, orlistat/DMH/HFD group, hydroxycitrate (HCA) group, HCA/DMH group, HCA/DMH/HFD group, thymol group, thymol/DMH group, thymol/DMH/HFD group. (E) Orlistat group: colonic wall showing glands with serrated luminal configuration (black arrow) with single cell lining (red arrow), scattered mitotic figures (green arrow), and mild interstitial inflammatory infiltrate (yellow arrow); (F) Orlistat/DMH group: colonic wall showing glands lined by mucous-secreting epithelium with normal-looking goblet cells (red arrow), and mild interstitial inflammatory infiltrate with scattered eosinophils (yellow arrow); (G) Orlistat/DMH/HFD group: colonic wall showing glands lined by slightly basophilic cells with focal nuclear stratification (yellow arrow), mild inflammatory infiltrate (red arrow) and mildly dilated congested blood vessels (blue arrow), and thickened muscularis mucosa (black arrow); (H) HCA group: colonic wall showing wide glands lined by single cell layer with normal-looking goblet cells (black arrow) and mild inflammatory infiltrate with scattered eosinophils (blue arrow), and thickened muscularis mucosa (yellow arrow).; (I) HCA/DMH group: colonic wall showing glands lined by single cell layer with regular nuclei and scattered mitotic figures (yellow arrow), and moderate interstitial inflammatory infiltrate with scattered eosinophils (red arrow), and average muscularis mucosa (blue arrow).; (J) HCA/DMH/HFD group: colonic wall showing glands with moderately apoptotic epithelial lining (black arrow) and mild interstitial inflammatory infiltrate with scattered eosinophils (red arrow) and moderately dilated congested blood vessel (yellow arrow), and thickened muscularis mucosa (blue arrow).Hematoxylin-eosin staining, magnification: X400