Figure 1.2. Histology of colon samples of the orlistat group, orlistat/DMH group, orlistat/DMH/HFD group, hydroxycitrate (HCA) group, HCA/DMH group, HCA/DMH/HFD group, thymol group, thymol/DMH group, thymol/DMH/HFD group. (E) Orlistat group: colonic wall showing glands with serrated luminal configuration (black arrow) with single cell lining (red arrow), scattered mitotic figures (green arrow), and mild interstitial inflammatory infiltrate (yellow arrow); (F) Orlistat/DMH group: colonic wall showing glands lined by mucous-secreting epithelium with normal-looking goblet cells (red arrow), and mild interstitial inflammatory infiltrate with scattered eosinophils (yellow arrow); (G) Orlistat/DMH/HFD group: colonic wall showing glands lined by slightly basophilic cells with focal nuclear stratification (yellow arrow), mild inflammatory infiltrate (red arrow) and mildly dilated congested blood vessels (blue arrow), and thickened muscularis mucosa (black arrow); (H) HCA group: colonic wall showing wide glands lined by single cell layer with normal-looking goblet cells (black arrow) and mild inflammatory infiltrate with scattered eosinophils (blue arrow), and thickened muscularis mucosa (yellow arrow).; (I) HCA/DMH group: colonic wall showing glands lined by single cell layer with regular nuclei and scattered mitotic figures (yellow arrow), and moderate interstitial inflammatory infiltrate with scattered eosinophils (red arrow), and average muscularis mucosa (blue arrow).; (J) HCA/DMH/HFD group: colonic wall showing glands with moderately apoptotic epithelial lining (black arrow) and mild interstitial inflammatory infiltrate with scattered eosinophils (red arrow) and moderately dilated congested blood vessel (yellow arrow), and thickened muscularis mucosa (blue arrow).Hematoxylin-eosin staining, magnification: X400 : Orlistat and Hydroxycitrate Ameliorate Colon Cancer in Rats: The Impact of Inflammatory Mediators : Science and Education Publishing

Figure 1.2. Histology of colon samples of the orlistat group, orlistat/DMH group, orlistat/DMH/HFD group, hydroxycitrate (HCA) group, HCA/DMH group, HCA/DMH/HFD group, thymol group, thymol/DMH group, thymol/DMH/HFD group. (E) Orlistat group: colonic wall showing glands with serrated luminal configuration (black arrow) with single cell lining (red arrow), scattered mitotic figures (green arrow), and mild interstitial inflammatory infiltrate (yellow arrow); (F) Orlistat/DMH group: colonic wall showing glands lined by mucous-secreting epithelium with normal-looking goblet cells (red arrow), and mild interstitial inflammatory infiltrate with scattered eosinophils (yellow arrow); (G) Orlistat/DMH/HFD group: colonic wall showing glands lined by slightly basophilic cells with focal nuclear stratification (yellow arrow), mild inflammatory infiltrate (red arrow) and mildly dilated congested blood vessels (blue arrow), and thickened muscularis mucosa (black arrow); (H) HCA group: colonic wall showing wide glands lined by single cell layer with normal-looking goblet cells (black arrow) and mild inflammatory infiltrate with scattered eosinophils (blue arrow), and thickened muscularis mucosa (yellow arrow).; (I) HCA/DMH group: colonic wall showing glands lined by single cell layer with regular nuclei and scattered mitotic figures (yellow arrow), and moderate interstitial inflammatory infiltrate with scattered eosinophils (red arrow), and average muscularis mucosa (blue arrow).; (J) HCA/DMH/HFD group: colonic wall showing glands with moderately apoptotic epithelial lining (black arrow) and mild interstitial inflammatory infiltrate with scattered eosinophils (red arrow) and moderately dilated congested blood vessel (yellow arrow), and thickened muscularis mucosa (blue arrow).Hematoxylin-eosin staining, magnification: X400

Journal of Food and Nutrition Research. 2022, 10(1), 41-49 doi:10.12691/jfnr-10-1-6