Figure 1.1. Histology of colon of the control (saline), DMH group, HFD group, DMH+HFD group. (A) Control: colonic wall show glands lined by tall columnar mucous-secreting epithelial cells (black arrow); (B) DMH group: colonic wall showed glands lined by epithelial cells with loss of mucous secretion (black arrow), focal nuclear stratification with prominent nucleoli (yellow arrow), and few mitotic figures (blue arrow), ACF; adenoma with moderate to severe dysplasia; (C) HFD group: colonic wall showing glands with reduction of mucous secretion of epithelial lining with focal nuclear stratification (black arrow) and prominent nucleoli (yellow arrow), and scattered mitotic figures (blue arrow), ACF; adenoma with mild to moderate dysplasia; (D) DMH/HFD group: colonic wall showing glands lined by epithelial cells with reduction of mucous secretion and elongated nuclei (red arrow), frequent mitotic figures (yellow arrow), mildly edematous interstitium (black arrow), and markedly dilated congested blood vessels (blue arrow), ACF; adenoma with moderate to severe dysplasia

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Orlistat and Hydroxycitrate Ameliorate Colon Cancer in Rats: The Impact of Inflammatory Mediators

Hesham Fathy Hassan Hassan, Ahmed Mohamed Mansour, El-Sayed Mohamed El-Sayed

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