Figures index

From

Ameliorative Effects of Schizandra chinensis Extracts and Their Soybean Powder Blends to Diabetes Mellitus

Min Jung Kim, Kwang-Hyun Park, Hye Jeong Yang, Dai Ja Jang, Hak Yong Lee, Young Mi Park, Byeong Soo Kim, Dong Yeop Shin

Journal of Food and Nutrition Research. 2022, 10(1), 8-18 doi:10.12691/jfnr-10-1-2
  • Figure 1. Inhibition of (A) α-glucosidase, (B) α-amylase and (C) oxidative stress by omija extracts and soybean powder, and their blends. Within the same concentration, a,b,c,d,e,f,g,h,i,j values not followed by the same capital letter are significantly different (p<0.05)
  • Figure 2. Screening of formula optimization of omija extracts and soybean powder on glucose tolerance and statistics. (A) Effect of three formula mixtures were orally administrated on OGTT in ICR mice. (B) Statistic analysis of OGTT results The results are expressed as mean ± SEM. a,b,c Values not followed by the same capital letter are significantly different (p<0.05)
  • Figure 3. Dose dependent effects of OSM on glucose tolerance and statistics. (A) OSM were orally administrated on OGTT in ICR mice and (B) statistic analysis of OGTT results The results are expressed as mean ± SEM. a,b,c,d Values not followed by the same capital letter are significantly different (p<0.05)
  • Figure 4. Effect of OSM administration on organ weights of liver, pancreas, kidney and epidydimal fat in diabetic mice. After induction of diabetes, indicated dose of OSM or metformin were given daily. The untreated diabetic control group received equal volume water orally daily. Within the same concentration, values not followed by the same capital letter are significantly different (p<0.05)
  • Figure 5. Effect of OSM administration on blood insulin levels, calculative HOMA-IR and HOMA-β cell index in diabetic mice. After induction of diabetes, indicated dose of OSM or metformin were given daily. The untreated diabetic control group orally daily received same volume water. Within the same concentration, values not followed by the same capital letter are significantly different (p<0.05)
  • Figure 6. Diabetic mice pancreatic tissues stained by immunohistochemistry for insulin using anti-insulin antibody than counter stained H&E methods. (A) normal mice, (B) control mice, (C) OSM 10, (D) OSM 30, (E) OSM 100, (F) metformin and (G) statistical analysis of β-cell area following Materials and Methods. Scale bar = 100 μm. a,b,c Values not followed by the same capital letter are significantly different (p<0.05)
  • Figure 7. Effect of OSM on AMPK, AKT phosphorylation and GLUT2 expression on liver tissue in diabetic mice. A Western blot and densitometry analysis of (B) p-AMPK/AMPK ratio, (C) p-Akt/Akt ratio and (D) GLUT2/ β-actin ratio. Representative immunoblots are shown. a,b,c Values not followed by the same capital letter are significantly different (p<0.05). N: normal, C: control, L: OSM 10, M: OSM 30, H: OSM 100 and P: positive