Figure 3.ARC inactivates ERK 1/2 and induces activation of caspase cascade. A, B: Cellular proteins were collected from tube-forming HUVECs that were treated with various concentrations of ARC(3.13, 12.5, and 50 µg/mL) for 6, 12, and 24 h. (A) Changes in phosphorylation state of ERK 1/2, p38, and Akt and (B) caspase-3, PARP, andlamin A/Cwere analyzed by Western blotting. Each experiment was repeated at least three times and representative data are shown

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Artepillin C Suppresses Angiogenesis by Inhibiting Tube-Formation and Inducing Apoptosis of Endothelial Cells

Mok-Ryeon Ahn, Sun Wook Kim, Shigenori Kumazawa, Toshiro Ohta

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