Figure 2. ARC induces apoptosis in tube-forming HUVECs. A: The tube-forming cells were treated with various concentrations of ARC (3.13, 12.5, and 50 µg/mL) for 24 h, fixed and stained with DAPI to observe cell nuclei. (a) 0 µg/mL, (b) 3.13 µg/mL, (c) 12.5 µg/mL, (d) 50 µg/mL. Representative photos are shown. Bar indicates 50 μm. B: Rates of apoptosis (percentage of condensed and fragmented cell nuclei against total cell nuclei) were quantified. A total of more than 500 cells from six fields were counted for each data point. Values are expressed as means ± SE (n = 6). *P < 0.05, **P < 0.01vs. the control group

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Artepillin C Suppresses Angiogenesis by Inhibiting Tube-Formation and Inducing Apoptosis of Endothelial Cells

Mok-Ryeon Ahn, Sun Wook Kim, Shigenori Kumazawa, Toshiro Ohta

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