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From
Purification of an Antiproliferative Lectin from
Erophaca
B
aetica
(Leguminosae) Seeds
Cristina Megías, Isabel Cortés-Giraldo, Julio Girón-Calle, Manuel Alaiz, Javier Vioque
Journal of Food and Nutrition Research
.
2013
, 1(5), 87-91 doi:10.12691/jfnr-1-5-2
Figure
1.
Gel filtration chromatography of
E. baetica
albumin extract using Superose 12 (A). Fractions corresponding to the first peak were pooled together and re-chromatographed twice more (B and C)
Full size figure and legend
Figure
2.
SDS-PAGE of the putative
E. baetica
lectin purified by gel filtration chromatography as shown in . Molecular weight standards are shown on the left
Full size figure and legend
Figure
3.
Effect of
E. baetica
lectin on the proliferation of human leukemic THP-1 cells. Cells were incubated in the presence of 3, 6, 9, 12 μg / mL lectin for up to 5 days. Positive control corresponds to cells treated with vehicle (PBS), negative control corresponds to cells treated with the apoptosis inducing agent camptothecin (20 M). Results are the mean ± SEM for n = 6. *** (p < 0.005), significantly different as compared to positive control
Full size figure and legend
Figure
4.
Dendrogram produced by cluster analysis of the amino acid composition of different legume lectins.
A. mongholicus
(Yan et al., 2005),
C. arborescens
(Bloch et al., 1976),
O. arenaria
(AN.: AAL79163.1),
M. sativa
(AN.: CAA76366.1),
L. sativus
(AN.: CAD27485.1),
V. faba
(AN.: CAD27484.1),
P. sativum
(AN.: AAA33675.1),
L. culinaris
(AN.: CAC42124.2)
Full size figure and legend