Figure 5. Histogram showing amplification of BRCA1 gene at exon1 and 2. Exon 1 is deleted in 24% of breast cancer tissues while exon 2 is deleted in nearly 41% of them. Absence of Exon 2 impairs gene transcription and further protein translation

From

BRCA1 Protein Deficiency in Breast Cancer Microbiopsy Lysate Delineates Patient Survival Time

Sara Hounguè, Terence Totah, Sophia George, Jean-Léon Olory-Togbé, Callinice D. Capo-chichi

Journal of Cancer Research and Treatment. 2021, 9(1), 1-11 doi:10.12691/jcrt-9-1-1