Figure 2. Citrate induces glioma cell death. (A) Effect of serial doses of citrate on C6 glioma viability. Viability levels in untreated controls were taken as 100%. Data are (Mean ± SEM) of the percentages of the control values of three independent experiments. *p <0.05, ** p<0.01 and ***p<0.001 indicate significance between control and different treatment conditions and also between treatment conditions within the same group. (B) Effect of citrate on morphology of C6 glioma

From

The Antioxidant Glycolysis Inhibitor (Citric Acid) Induces a Dose-dependent Caspase-mediated Apoptosis and Necrosis in Glioma Cells

Salah Mohamed El Sayed, Hussam H. Baghdadi, Nassar Ayoub Abdellatif Omar, Amal Nor Edeen Ahmad Allithy, Nahed Mohammed Hablas, Ahmed Ragab Fakhreldin, Reham Abelsalam Mariah, Momen El-Shazley, Mongi Ayat, Sayed Mostafa, Mostafa Abu-el Naga, Mohamed Abdel-Halim

Journal of Cancer Research and Treatment. 2018, 6(1), 18-24 doi:10.12691/jcrt-6-1-4