Figure 2. H&E stained sections from the colon of a) The control group showing normal appearance of the colonic mucosa, crypts and the mucosal glands; b) UC patients before treatment with mucosal ulceration, massive infiltration with neutrophils with severe destruction of the crypts and the mucosal glands; c) Metformin treated group with intact mucosal surface, mild to moderate inflammatory cellular infiltration with congested blood vessels in the submucosa; d) I3C treated group with minimal mucosal ulceration, increased goblet cell population and moderate inflammatory cellular infiltration; e) Metformin/I3C treated group with apparently normal mucosal glands and crypts with marked decrease in the inflammatory cellular infiltration (H&E X200)

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Effect of Indole-3-carbinol and/or Metformin on Female Patients with Ulcerative Colitis (Premalignant Condition): Role of Oxidative Stress, Apoptosis and Proinflammatory Cytokines

Ahmed M. Kabel, Mohamed S. Omar, Sultan N. Alotaibi, Mohammed H. Baali

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