Figures index

From

Abrogation by Ginkgo Byloba Leaf Extract on Hepatic and Renal Toxicity Induced by Methotrexate in Rats

Ehab Tousson, Zeinab Atteya, Afaf El-Atrash, Ola I. Jeweely

Journal of Cancer Research and Treatment. 2014, 2(3), 44-51 doi:10.12691/jcrt-2-3-1
  • Figures 1A-1F. Photomicrographs of rat Liver sections in the different experimental groups stained with Haematoxylin & Eosin. A: Rat Liver sections in control group revealed normal structure of hepatocytes. B: Rat Liver section in GLE group revealed normal structure of hepatocytes (hp). C: Liver sections of MTX group showed moderate to severe lose of liver architecture, disturbance of the hepatocytes, congestion (Black arrows) in central veins (CV), atrophied, and vacuolated hepatocytes (White arrows). D&E: Liver sections in co-treated and post treated rat with GLE groups revealed a moderate to mild degree of improvement in hepatocytes where a few vacuolated hepatocytes (White arrows) and mild congestion in central veins were observed. F: Liver section in self treated showed severe lose of liver architecture, marked disturbance of the hepatocytes and strong marked hepatocellular vacuolation (White arrows)
  • Figures 2A-2F. Photomicrographs of rat kidney sections in the different groups under study stained with Haematoxylin & Eosin. A&B: Rat kidney sections in control and GLE groups respectively showed normal structure of renal cortex which comprised renal corpuscles (White arrows), proximal and distal convoluted tubules. C: Rat kidney sections in MTX group showed glomerular damage (White arrows), vacuolization in tubular cells focal necrosis and cell infiltration (Black arrows). D: Kidney section of co-treated group with GLE revealed a good degree of improvement glomerular damage with minimal vacuolization(Arrow heads) in tubular cells. E: Rat kidney section in post treated group with GLE showed moderate organized tubular and glomerular structures except mild inflammatory infiltration (Black arrows). F: Kidney section of MTX self treated showed severe lose of kidney architecture, marked disturbance in glomeruli with strong inflammatory infiltration (Black arrows)
  • Figures 3(A-F). Photomicrographs of rat Liver sections in the different experimental groups stained with CD68-ir. A&B: Negative CD68-ir reaction in control and GLE respectively. C: Severe positive reactions for Cd68-ir in MTX group. D&E: Mild to moderate positive reactions for CD68-ir in Co-treated and post treated rats with GLE respectively. F: Strong positive reaction for CD68-ir in MTX self treated rats
  • Figures 4(A-F). Photomicrographs of rat kidney sections in the different experimental groups stained with CD68-ir. A&B: Negative CD68-ir reaction in control and GLE respectively. C: Severe positive reactions for Cd68-ir in MTX group. D&E: Moderate to mild positive reactions for CD68-ir in Co-treated and post treated MTX with GLE respectively. F: Strong positive reaction for CD68-ir on the kidney in MTX self treated rats