Figure 4. Some acetate derivatives of biological importance. Acetyl CoA, acetoacetate, β-hydroxybutyrate and dichloroacetate (DCA) are acetate analogs. An evident pharmacological antagonism was reported between acetate and DCA. An evident pharmacological antagonism was reported between ketone bodies and DCA as regard effects on arterial blood pH where DCA treats metabolic acidosis

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Dichloroacetate is a Novel Safe Treatment for Beta-ketothiolase Deficiency: Towards Better Therapeutic Outcomes (An Original Article)

Salah Mohamed El Sayed, Elsayed Abdelkreem, Moutasem Salih Aboonq, Sultan S. Al Thagfan, Yaser M. Alahmadi, Osama Alhadramy, Hussam Baghdadi, Mohammed Hassan, Faten M. Omran, Hytham Mahmoud Abdel-Latif, Wafaa Abdel-ziz, Azza Mahmoud Ahmed Abouelella, Amr El-Dardear, Mohamed Abdel-haleem, Elhussainy MA Elhussainy, Hassan El-Alaf, Manal Mohamed Helmy Nabo

International Journal of Clinical and Experimental Neurology. 2020, 8(1), 4-8 doi:10.12691/ijcen-8-1-2