Figure 3. Relation between antibody titers (times reference) on the vertical axis and DQ haplotype binding scores () on the horizontal axis. The circles represent median ± SE of tTGA/EMA for each haplotype binding score. Thus, subjects with haplotype binding score of 4 are DQ2.5/2.5 homozygotes while subjects with score of 0 are DQX.x homozygotes lacking any CD-associated haplotypes. The slope of the linear regression is significantly different from zero (p<0.05) and suggests that antibody production is proportional to allele dose of the HLA DQ A1 and B1 genes

From

Relationship Between Genotype and Disease Phenotype for Gluten-Related Disorders

Michael F. Roberts, Nadine Grzeskowiak, Stephen E. Bricher

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