Figures index

From

Methotrexate-induced Hepatic and Renal Toxicity: Role of L-carnitine in Treatment

Ehab Tousson, Zaki Tawfeek Zaki, Walid Ali Abu-Shaeir, Hamada Hassan

Biomedicine and Biotechnology. 2014, 2(4), 85-92 doi:10.12691/bb-2-4-4
  • Figure 1. Changes in mortality% in different groups under study. G1, control group; G2, l-carnitine group; G3, MTX group; G4, Co-treated group with l-carnitine; G5, Post treated group with l-carnitine; G6, MTX self treated group.
  • Figures 1A-1F. Photomicrographs of rat Liver sections in the different experimental groups stained with Haematoxylin & Eosin. A: Rat Liver sections in control group revealed normal structure of hepatocytes. B: Rat Liver section in LC group revealed normal structure of hepatocytes (hp). C: Liver sections of MTX group showed moderate to severe lose of liver architecture, disturbance of the hepatocytes, congestion (Black arrows) in central veins (CV), atrophied, and vacuolated hepatocytes (White arrows). D&E: Liver sections in co-treated and post treated rat with LC groups revealed a moderate to mild degree of improvement in hepatocytes where a few vacuolated hepatocytes (White arrows) and mild congestion in central veins were observed. F: Liver section in self treated showed severe lose of liver architecture, marked disturbance of the hepatocytes and strong marked hepatocellular vacuolation (White arrows)
  • Figures 2A-2F. Photomicrographs of rat kidney sections in the different groups under study stained with Haematoxylin & Eosin. A&B: Rat kidney sections in control and LC groups respectively showed normal structure of renal cortex which comprised renal corpuscles (White arrows), proximal and distal convoluted tubules. C: Rat kidney sections in MTX group showed glomerular damage (White arrows), vacuolization in tubular cells focal necrosis and cell infiltration (Black arrows). D: Kidney section of co-treated group with LC revealed a good degree of improvement glomerular damage with minimal vacuolization(Arrow heads) in tubular cells. E: Rat kidney section in post treated group with LC showed moderate organized tubular and glomerular structures except mild inflammatory infiltration (Black arrows). F: Kidney section of MTX self treated showed severe lose of kidney architecture, marked disturbance in glomeruli with strong inflammatory infiltration (Black arrows)