Figure 3. Photomicrographs showing the morphological features of the undifferentiated BM-MSCs: (a)The undifferentiated BM-MSCs stained with H&E and examined with light microscope, shows static morphology as bipolar fibroblastic structure (Scale bar = 50µm).(b) The undifferentiated BM-MSCs examined with SEM shows flatten or spindle-shape cells (Scale bar = 50µm).(c) Clusters of undifferentiated BM-MSCs examined with CLSM, expressed positive CD146 immunoreactivity and exhibited as spindle or fibroblastic-like morphology (Scale bar = 100µm).(d) Higher magnification of undifferentiated BM-MSCs examined with CLSM, and having static morphology as bipolar fibroblastic structure with positive CD146 (Scale bar = 50µm)

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Transdifferentiation of Bone Marrow Mesenchymal Stem Cells into Neural Cells via Cerebrospinal Fluid

Dina Y. Otify, EmanA. Youssef, Naglaa B. Nagy, Mona K. Marei, Magda I. Youssif

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