Figure 4. Citrate exerts a synergistic effect with 3-bromopyruvate (A) Glycolysis double inhibition through combining serial doses of citrate with 3-bromopyruvate in C6 glioma cells. (B) Effect of glycolysis double inhibition on U373MG human GBM cells. (C) Effect of glycolysis double inhibition on morphology of U373MG. Data are (Mean ± SEM) of the percentages of the control values of three independent experiments. *p<0.05, ** p<0.01 and ***p<0.001 indicate significance between control and different treatment conditions and also between treatment conditions within the same group

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Pharmacological Double Inhibition of Glycolysis in glioblastoma Multiforme Cells Maximizes Cancer Cell Killing: A Synergism between Citrate and 3-bromopyruvate

Faten M. Omran, Hussam Baghdadi, Tamer M. Soliman, Osama Alhadramy, Momen El-shazley, Samer A. El-Sawy, Hytham Mahmoud Abdel-Latif, Wafaa A. Abdellah, Azza Mahmoud Ahmed Abouelella, Amr El-Dardear, Mohamed Abdel-haleem, Elhussainy MA Elhussainy, Hassan El-Alaf, Nassar Ayoub, Sayed Mostafa El Sayed, Hesham I. Abdallah, Salah Mohamed El Sayed, Mongi Ayat, Ahmed Mohamed Shehata

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