Figure 3. Glycolysis inhibitors decrease cancer cells viability. A. Pyruvate, 3-bromopyruvate and lactate are structural analogs. Lactate-based benefits to cancer cells include enhancing angiogenesis, metastasis, invasion, proliferation, migration, chemoresistance, radioresistance and acidic tumor microenvironment. B. Effects of serial citrate concentrations on viability of human glioblastoma cells (U373MG)

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Pharmacological Double Inhibition of Glycolysis in glioblastoma Multiforme Cells Maximizes Cancer Cell Killing: A Synergism between Citrate and 3-bromopyruvate

Faten M. Omran, Hussam Baghdadi, Tamer M. Soliman, Osama Alhadramy, Momen El-shazley, Samer A. El-Sawy, Hytham Mahmoud Abdel-Latif, Wafaa A. Abdellah, Azza Mahmoud Ahmed Abouelella, Amr El-Dardear, Mohamed Abdel-haleem, Elhussainy MA Elhussainy, Hassan El-Alaf, Nassar Ayoub, Sayed Mostafa El Sayed, Hesham I. Abdallah, Salah Mohamed El Sayed, Mongi Ayat, Ahmed Mohamed Shehata

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