Figures index

From

Network Pharmacology Integrated Pharmacokinetics Approach to Decipher the Mechanism of Shankhapushpi Exerted Nootropic Activity

Srinidhi

American Journal of Pharmacological Sciences. 2019, 7(1), 25-38 doi:10.12691/ajps-7-1-5
  • Figure 1. Pictorial illustration of the Shankhapushpi botanicals-phytochemicals network. The Shankhapushpi Botanicals are represented as triangular pink nodes and their associated phytochemicals are represented as blue square nodes.
  • Figure 2. Pictorial illustration of the Shankhapushpi botanicals and their associated druglikeness screened phytochemicals network. The Shankhapushpi Botanicals are represented as triangular pink nodes and their associated drug-likeness screened phytochemicals are represented as blue square nodes.
  • Figure 3. Pictorial illustration of the complete Shankhapushpi phytochemicals-targets network. The phytochemicals are represented as triangular blue nodes and their predicted targets are represented as red square nodes.
  • Figure 4. Pictorial illustration of the druglikeness screened Shankhapushpi phytochemicals-targets network. The druglikeness screened phytochemicals are represented as triangular blue nodes and their predicted targets are represented as red square nodes.
  • Figure 5. Genemania predicted protein-protein interaction network illustrating the Shankhapushpi nootropic targets. The input target proteins are represented as circular black nodes and their predicted targets are represented as circular grey nodes.
  • Figure 6. Genemania analysis of the predicted Protein-protein interaction network illustrating various genial parameters in the network
  • Figure 7. Nodal degree distribution of the Shankhapushpi nootropic genes
  • Figure 8. False discovery rate/Benjamini Score distribution of the predicted Gene Ontology and enrichment analysis terms from the DAVID tool
  • Figure 9. P Score distribution of the predicted Gene Ontology and Enrichment analysis terms from the DAVID tool
  • Figure 10. False Discovery Rate/Benjamini Score distribution of the Genemania predicted Gene Ontology and enrichment analysis terms
  • Figure 11. Pictorial representation of the Shankhapushpi nootropic genes and their associated nootropic activity related pathways. The Shankhapushpi nootropic genes are represented as circular green nodes and their predicted pathways are represented as triangular red nodes
  • Figure 12. Pictorial representation of the Shankhapushpi nootropic genes and their associated nootropic activity related pathways. The Shankhapushpi nootropic genes are represented as circular green nodes and their predicted nootropic pathways are represented as triangular red nodes. The predicted pathways unrelated to nootropic activity are represented as blue nodes
  • Figure 13. Pictorial illustration of the Shankhapushpi nootropic genes (represented as green triangular nodes) – nootropic disorders (represented as red square nodes), depression and anxiety disorders (represented as yellow square nodes), and, neurodegenerative diseases (represented as square blue nodes).
  • Figure 14. Consolidated network comprising of the Shankhapushpi botanicals (represented as triangular pink nodes), total Shankhapushpi phytochemicals (represented as square blue nodes), targets (represented as square red nodes) and associated pathways (represented as square yellow nodes).
  • Figure 15. Consolidated network comprising of Shankhapushpi botanicals (represented as triangular pink nodes), total druglikeness screened Shankhapushpi phytochemicals (represented as square blue nodes), targets (represented as square red nodes), neurodegenerative diseases (represented as green nodes) depression and anxiety disorders (represented as yellow nodes) and nootropic disorders (represented as light blue nodes).