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Losartan versus Enalapril in the Protection of the Gastric Mucosa against Aspirin-Induced Gastric Mucosal Injury in Rats

Mahmoud H. Abdel-Rahim, Sanaa A. Ahmed, Hytham M. Abdel-Latif

American Journal of Pharmacological Sciences. 2016, 4(3), 39-45 doi:10.12691/ajps-4-3-3
  • Figure 1. Effect of i.p. injection of losartan (3mg/kg/day)orenalapril (10 mg/kg/day) for 4 weeks duration on mucosal prostaglandin E2 (PGE2) level (ng/g wet tissue) in aspirin-induced gastric ulcer in rats. n=6 rats in each group. * Significant difference at P< 0.05 compared to control group.● Significant difference at P< 0.05 compared toaspirin group
  • Figure 2. Effect of i.p. injection of losartan (3mg/kg/day)or enalapril (10 mg/kg/day) for 4 weeks duration on mucosal superoxide dismutase (SOD) activity (U/g wet tissue) in aspirin- induced gastric ulcer in rats. n= 6 rats in each group. * Significant difference at P< 0.05 compared to control group.● Significant difference at P< 0.05 compared to aspirin group
  • Figure 3. Effect of i.p. injection of losartan (3mg/kg/day)or enalapril (10 mg/kg/day) for 4 weeks duration on mucosal catalase (CAT) activity (U/g wet tissue) in aspirin-induced gastric ulcer in rats. n=6 rats in each group. * Significant difference at P< 0.05 compared to control group.● Significant difference at P< 0.05 compared to aspirin group
  • Figure 4. Effect of i.p. injection of losartan (3mg/kg/day)orenalapril (10 mg/kg/day) for 4 weeks duration on mucosal nitric oxide (NO) level (nmol/g wet tissue) in aspirin- induced gastric ulcer in rats.n=6 rats in each group. * Significant difference at P< 0.05 compared to control group.● Significant difference at P< 0.05 compared toaspirin group
  • Figure 5A. Gastric mucosa of rat from control group showing smooth gastric mucosa with no inflammation. The incidence of ulceration was zero%
  • Figure 5B. Gastric mucosa from rat received losartan for 4 weeks duration showing smooth gastric mucosa with no inflammation. The incidence of ulceration was zero%
  • Figure 5C. Gastric mucosa of rat received enalapril for 4 weeks duration, smooth gastric mucosa with no inflammation. The incidence of ulceration was zero%
  • Figure 5D. Gastric mucosa of aspirin–induced ulcer rat showing ulcer (arrow) surrounded by area of severe inflammation, the incidence of ulceration was 83%
  • Figure 5E. Gastric mucosa of rat pretreated with losartan 3mg/kg/day for 4 weeks duration before induction of ulcer by aspirin showing a decrease in the severity of inflammation area with a decrease in the incidence of ulceration to become 17%
  • Figure 5F. Gastric mucosa of rat pretreated with enalapril 10 mg/kg/day for 4 weeks duration before induction of ulcer by aspirin showing a decrease in the severity of inflammation with a decrease in the incidence of ulceration to become17%
  • Figure 6A. Gastric biopsy from a rat in control group shows intact mucosal surface HandE x40
  • Figure 6B. Gastric biopsy from a rat treated with losartan in a dose of 3 mg/kg/day for 4 weeks duration showing intact mucosal surface HandEx40
  • Figure 6C. Gastric biopsy from a rat treated with enalapril in a dose of 10 mg/kg/day for 4 weeks duration showing intact mucosal surface HandEx40
  • Figure 6D. Gastric biopsy from aspirin-induced ulcer rat, showing epithelial damage, necrotic damage of mid and lower mucosa and congestion of submucosa HandEx100
  • Figure 6E. Gastric biopsy from rat pretreated with losartan in a dose of 3 mg/kg/day for 4 weeks duration before induction of ulcer by aspirin showing superficial gastric epithelial erosion HandEx100
  • Figure 6F. Gastric biopsy from rat pretreated with enalapril in a dose of 10 mg/kg/day for 4 weeks duration before induction of ulcer by aspirin, showing superficial gastric mucosal erosions. HandEx100