Table 4. summarizes key interactions for selected peptides against PBP1B, highlighting why uncomplexed peptides succeed and why Cu²⁺ complexation generally impairs binding

From

Docking-Based Evaluation of Defensin-Derived Peptides and Their Cu²⁺ Complexes as Dual-Target Inhibitors of Exo-β-(1,3)-Glucanase and Penicillin-Binding Protein Transglycosidase 1B

Olatomide A. Fadare, Temitayo O. Aiyelabola, Imisioluwa A. Akintola, Janet I. Michael, Rachael Y. Fadare, Chiamaka V. Chukwu, Folakemi O. Yakubu, Deborah A. Sanni, Roheemah O. Lawal, Akitsu Takashiro, Adenike Kuku

American Journal of Pharmacological Sciences. 2026, 14(1), 7-19 doi:10.12691/ajps-14-1-2