Figure 6. Histopathology of lung tissues (H&E staining). (A and B) show lung tissue of control group after 24 h and 28 days respectively with normal histological architecture, and normal intrapulmonary bronchioles, 4x. (C) Lung tissue of AgNO3-treated group after 24 h shows acute pneumonia where active hyperemia of interstitial capillaries and marked neutrophilic recruitment alveoli (arrow), 10x. (D) Lung tissue of AgNO3-treated group after 28 days shows normal pulmonary alveoli and normal intrapulmonary bronchioles, 4x. (E) Lung tissue of AgNPs-treated group after 24 h shows marked diffuse thickening in interstitial tissue with eosinophilic (arrow) and histiocytic infiltration and fibroblastic proliferation, 10x. (F) Lung tissue of AgNPs-treated group after 28 days shows focal recruitment of eosinophils (arrows) and histiocytic replacing pulmonary tissue, 10x : Time-dependent Toxic Effect and Distribution of Silver Nanoparticles Compared to Silver Nitrate after Intratracheal Instillation in Rats : Science and Education Publishing

Figure 6. Histopathology of lung tissues (H&E staining). (A and B) show lung tissue of control group after 24 h and 28 days respectively with normal histological architecture, and normal intrapulmonary bronchioles, 4x. (C) Lung tissue of AgNO₃-treated group after 24 h shows acute pneumonia where active hyperemia of interstitial capillaries and marked neutrophilic recruitment alveoli (arrow), 10x. (D) Lung tissue of AgNO₃-treated group after 28 days shows normal pulmonary alveoli and normal intrapulmonary bronchioles, 4x. (E) Lung tissue of AgNPs-treated group after 24 h shows marked diffuse thickening in interstitial tissue with eosinophilic (arrow) and histiocytic infiltration and fibroblastic proliferation, 10x. (F) Lung tissue of AgNPs-treated group after 28 days shows focal recruitment of eosinophils (arrows) and histiocytic replacing pulmonary tissue, 10x

American Journal of Nanomaterials. 2016, 4(1), 12-19 doi:10.12691/ajn-4-1-3