Figure 3. Diagram of the proposed signaling cascade involved in the inhibitory effect of EPA on the progression of osteoarthritis(OA). EPA prevented SNP-induced chondrocyte apoptosis and matrix loss by inhibiting phosphorylation of p38 MAPK and p53, caspase 3 and PARP cleavage and expression of MMP3 and MMP13. SNP, sodium nitroprusside; MMP, Matrix metalloproteinase; P-P38 MAPK, the phosphorylation of p38 Mitogen-activated protein kinase; P-P53(ser46), the phosphorylation of p53 at ser46; PARP, poly(ADP-ribose)-polymerase

From

Researches on the Pharmacological Effects of Eicosapentaenoic Acid

Zunting Pang, Qiang Zhang, Zhixiang Tian, Chunchao Han

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