Figures index

From

Researches on the Pharmacological Effects of Eicosapentaenoic Acid

Zunting Pang, Qiang Zhang, Zhixiang Tian, Chunchao Han

American Journal of Medicine Studies. 2015, 3(1), 4-7 doi:10.12691/ajms-3-1-2
  • Figure 1. The formation of EPA. EPA is derived from α-LNA. α-LNA, α-linolenic acid
  • Figure 2. Model illustrating plausible mechanisms mediating anti-inflammatory and adipocyte hypotrophic effects of EPA. We showed here that EPA is able to ameliorate glucose homeostasis and metabolic profile in part by reducing adipose tissue inflammation, possibly via reduction in PG synthesis and reduced lipid accumulation and adipocyte size. GPR120, G-protein coupled receptor 120; MCP-1, monocyte chemoattractant protein 1; PAI-1, plasminogen activator inhibitor-1; ROS, reactive oxygen species
  • Figure 3. Diagram of the proposed signaling cascade involved in the inhibitory effect of EPA on the progression of osteoarthritis(OA). EPA prevented SNP-induced chondrocyte apoptosis and matrix loss by inhibiting phosphorylation of p38 MAPK and p53, caspase 3 and PARP cleavage and expression of MMP3 and MMP13. SNP, sodium nitroprusside; MMP, Matrix metalloproteinase; P-P38 MAPK, the phosphorylation of p38 Mitogen-activated protein kinase; P-P53(ser46), the phosphorylation of p53 at ser46; PARP, poly(ADP-ribose)-polymerase